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Results: 39

Investigating the role of DIPG-derived exosomes in tumor growth and ...

Diffuse Intrinsic Pontine Glioma (DIPG) is a highly aggressive and infiltrating brain tumor affecting children for which there is no effective treatment. Sequencing data have revealed  the existence of well defined subgroups of tumors based on age of onset, specific location in the brain, mutations and clinical outcome. Those ...

Validation of TAK228 as an effective drug for treating children ...

Validation of TAK228 as an Effective Drug for Treating Children Diagnosed with DIPG Diffuse intrinsic pontine glioma (DIPG) is an untreatable childhood cancer.  DIPGs develop in pons making them surgically unresectable.  We and others have identified mutations in histone and their obligate partner mutations that seem to drive ...

Credentialing an improved DIPG mouse model

DIPG is a rare type of childhood brain cancer that is currently incurable. One barrier for progress against DIPG is the development of predictive models, i.e. models in which observations regarding the evaluation of new therapies will accurately predict observations in clinical trials for children with DIPG.   ...

Imaging to Discern Immunotherapeutic-Induced Pseudoprogression in CNS Tumors

Brain tumors are the most common cause of childhood deaths by disease in the United States. Even when standard treatments successfully eliminate tumors, they often bestow devastating long-term effects, including an increased risk for the development of secondary cancers, without guaranteed prevention of relapse. ...