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Results: 39

A MOUSE MODEL OF HIST1H3B / ACVR1 MUTANT DIPG

Diffuse intrinsic pontine glioma (DIPG) is a malignant brainstem tumour arising in children representing a major unmet clinical need, with a 2-year survival rate close to zero. With chemotherapy ineffective and surgical intervention not possible, new therapeutic approaches are urgently needed based upon the unique biological mechanisms driving DIPG tumorigenesis. ...

An open label single arm phase I/II study of ...

We propose a phase I/limited efficacy clinical trial investigating repeated administration of MTX110, a soluble form of panobinostat, given via convection-enhanced delivery (CED) to pediatric patients with newly diagnosed diffuse intrinsic pontine glioma (DIPG). We hypothesize this therapy will be safe and well-tolerated and will be efficacious and prolong ...

Credentialing an improved DIPG mouse model

DIPG is a rare type of childhood brain cancer that is currently incurable. One barrier for progress against DIPG is the development of predictive models, i.e. models in which observations regarding the evaluation of new therapies will accurately predict observations in clinical trials for children with DIPG.   ...

Imaging to Discern Immunotherapeutic-Induced Pseudoprogression in CNS Tumors

Brain tumors are the most common cause of childhood deaths by disease in the United States. Even when standard treatments successfully eliminate tumors, they often bestow devastating long-term effects, including an increased risk for the development of secondary cancers, without guaranteed prevention of relapse. ...