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Results: 138

Targeting Group 4 medulloblastoma via Musashi1-cell cycle inhibition

Despite recent progress in medulloblastoma treatment, two main problems remain. High risk groups 3 and 4 medulloblastoma patients still show a high rate of mortality. Even in the case of success, patients are frequently left with devastating neurocognitive and other sequelae. Therefore, more effective and less aggressive therapies are still in demand. ...

Investigating the use of Copper chelation therapy in DIPG: a ...

The development of genomics has led to a comprehensive delineation of Diffuse Intrinsic Pontine Glioma (DIPG) heterogenous mutational landscape. This includes several interconnected cellular processes that can be pursued by drugs targeting cellular copper called chelating agents. These drugs bind copper and prevent its use in the cell. Copper ...

Epigenetic reprogramming as a treatment option for NF1

Neurofibromatosis type 1 (NF1) is common, occurring in 1/3000 live births, and results in skin pigmentation and the growth of tumors along nerves in the skin, brain, and other parts of the body. It arises from a mutated and non-functional tumor suppressor bearing its name.  Tumors of the peripheral nerves, called ...

Mapping DIPG Tumour Migration using Spatial Transcriptomics

Diffuse Intrinsic Pontine Glioma (DIPG) otherwise known as Diffuse Midline Glioma (DMG) is a fatal brain stem glioma arising in young children. There are no effective therapies for DIPG and children typically succumb to the disease within 2 years. No therapy to-date has improved the survival rate for children with DIPG ...

Targeting receptor tyrosine kinase signalling pathways in DIPG by using ...

Diffuse Intrinsic Pontine Glioma (DIPG) is the most dismal paediatric brain tumour, characterised by universal mortality and an average survival of less than one year. Several factors contribute to the unique challenges in treating DIPG, including localisation, infiltrative pattern of growth and chemoresistance. Treatment options are limited to palliative radiotherapy. ...