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Results: 185

Investigating the impact of radiation toxicity on immune response in ...

Abstract: Cancer is a disease caused by changes in the genes and a leading cause of death worldwide. Cancer treatment is challenging despite years of innovations and research. In advanced stage, it is largely incurable and poorer prognosis. Radiotherapy is one of the effective means of managing advanced stage ...

Radionuclide therapy for somatostatin receptor-positive high-grade central nervous system tumors ...

Abstract: Brain and spine tumors are the leading cause of cancer-related death in children and adolescents. While cure can sometimes be achieved with conventional chemotherapy, surgery, and/or radiation, prognosis is dismal for patients whose aggressive brain/spine tumors progress despite these treatments. There is a critical need to develop ...

Investigating the use of Copper chelation therapy in DIPG: a ...

The development of genomics has led to a comprehensive delineation of Diffuse Intrinsic Pontine Glioma (DIPG) heterogenous mutational landscape. This includes several interconnected cellular processes that can be pursued by drugs targeting cellular copper called chelating agents. These drugs bind copper and prevent its use in the cell. Copper ...

Mapping DIPG Tumour Migration using Spatial Transcriptomics

Diffuse Intrinsic Pontine Glioma (DIPG) otherwise known as Diffuse Midline Glioma (DMG) is a fatal brain stem glioma arising in young children. There are no effective therapies for DIPG and children typically succumb to the disease within 2 years. No therapy to-date has improved the survival rate for children with DIPG ...

Investigating the genomic blueprint of invasive and treatment-resistant tumor cells ...

Diffuse intrinsic pontine gliomas (DIPG) are incurable tumours that account for nearly 10% of all pediatric brain cancers. Current therapies are ineffective and the median survival remains under a year with near 100% fatality.  Understanding how DIPG tumour cells evolve to withstand selective pressures and become incurable entities is key ...