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Results: 85

Targeted protein degradation for DIPG therapy

Childhood brain tumors are the second most common type of pediatric cancer, with overall survival and treatment related long-term side effects far worse compared to other children with solid tumors and haematological malignancies. The prognosis of brain tumors in children has improved over the past decades; however, one third of ...

Development of immunocompetent animal models for pediatric high-grade glioma and ...

Brain tumors are the leading cause of cancer-related death in children, with high-grade glioma (pHGG) and diffuse intrinsic pontine glioma (DIPG) carrying the worst prognosis, with no chance of cure. Over the past years, the prognosis of other aggressive cancer types has improved thanks to scientific breakthroughs in the field ...

Repurposing antimalarial drugs for DIPG therapy

Diffuse intrinsic pontine gliomas (DIPGs) are rare but highly aggressive brain tumors found in the pons, an area of the brainstem that controls many of the body’s most vital functions such as breathing, blood pressure, and heart rate. Despite DIPG being the leading cause of pediatric death by ...

Exploiting the use of exosomal miRNAs from DIPG/DMG liquid ...

An unmet need in DIPG/DMG, is  the lack of reliable biomarkers. Those are urgently needed as alternative/complementary approach to neuroradiological imaging, not only for diagnosis but for disease monitoring. In this context, liquid biopsy could represent a valuable, non-invasive source for biomarkers in DIPG/DMG. From previous ...

Chromatin defects and therapeutic targets in pediatric brain cancers

DNA is wrapped around an octamer of histone proteins, known as a nucleosome, to form the basic repeating unit of chromatin. Genes encoding two chromatin regulators, ATRX and the histone H3.3, are frequently mutated in pediatric glioblastoma (pGBM) which is a lethal form of brain cancer. To translate this new ...