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Results: 65

Exploring the brain-gut-microbiota axis to characterize and predict outcome in ...

Abstract Diffuse intrinsic pontine gliomas (DIPGs), represent a group of malignancies with rapid onset of devastating neurologic symptoms associated with the local extension, poor response to adjuvant therapy and a very poor prognosis. Radiotherapy has remained the only modality of treatment with proven transient symptomatic improvement and represents the mainstay ...

Preclinical Investigation Toward a Clinical Trial of Combination, Multimodality Treatment ...

DIPG is an aggressive childhood brain tumor that is nearly always fatal. Although most past patients have died of the tumor pushing on the brainstem’s pons area, DIPG spreads to other parts of the brain and spinal cord, known as the central nervous system (CNS). To cure DIPG, ...

Modulating the DIPG microenvironment with virus and complement inhibitors as ...

Diffuse intrinsic pontine glioma (DIPG) is one of the most formidable challenges faced by pediatric oncologists. For the last 30 years, all treatment approaches for these type of tumors have failed, leaving a terrible prospect of survival at 5 years for these children virtually of zero. Thus, it is clear that new ...

Investigating the impact of radiation toxicity on immune response in ...

Abstract: Cancer is a disease caused by changes in the genes and a leading cause of death worldwide. Cancer treatment is challenging despite years of innovations and research. In advanced stage, it is largely incurable and poorer prognosis. Radiotherapy is one of the effective means of managing advanced stage ...

Protein degradation as a strategy to target mutant WIP1 in ...

Close to 20% of Diffuse Intrinsic Pontine Gliomas (DIPGs) harbor a mutation in a gene called PPM1D that leads to expression of a truncated form of a protein called WIP1. We have found PPM1D-mutant DIPG cells to require expression of WIP1, rendering it an attractive therapeutic target for these ...