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Results: 16

Targeting Glycolysis for Inhibition of Tumor Growth in Pediatric Brain ...

Pediatric brain tumors have limited responses to conventional therapeutic option and high mortality rates. Novel approaches to treat these and other forms of cancer involve targeting metabolic mechanisms of cancer cells from which they derive energy. These include aerobic glycolysis or the Warburg effect; named after Otto Warburg who first ...

Diffuse Intrinsic Pontine Glioma.

In tumors like DIPG, the diagnosis itself spells a death sentence for the child affected. For several decades, none of the altered fractionation radiotherapy or additional chemotherapy or targeted agents have shown a significant benefit over conventional radiotherapy. We propose amalgamation of several known and tested hypothesis in DIPG ...

Exploring Combination Therapy for DIPG: SGI-110 and GAA Vaccine

Diffuse intrinsic pontine glioma (DIPG) are some of the deadliest childhood brain tumors. The immune system protects the body by recognizing targets on harmful cells, but tumor cells can “switch off” the targets and hide from the immune system. We have been using a vaccine that can target ...

Development of immunocompetent animal models for pediatric high-grade glioma and ...

Brain tumors are the leading cause of cancer-related death in children, with high-grade glioma (pHGG) and diffuse intrinsic pontine glioma (DIPG) carrying the worst prognosis, with no chance of cure. Over the past years, the prognosis of other aggressive cancer types has improved thanks to scientific breakthroughs in the field ...

A Multi-institutional Feasibility Study Prospectively Measuring Quality of Life in ...

This study is being done to assess the feasibility of utilizing standardized age-appropriate Patient Reported Outcomes Measurement Information System (PROMIS) assessments in conjunction with consortium clinical trials to evaluate physical and mental health.  Secondary objectives will be 1) to estimate the baseline (pre-therapy), 2-week, 4-week, and 8-week physical and mental ...