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Results: 138

The current situation of childhood brain tumor long-term survivors in ...

Central nervous system tumors, represent the highest mortality rate of all childhood malignancies, Nevertheless, the number of survivors of pediatric Brain tumors continues to increase. Gradually improving survival rates and a growing population of long-term survivors have expanded the focus of research, Increased attention has been given to late ...

Glycomic Tumor Neoantigen Discovery in Diffuse Intrinsic Pontine Glioma (DIPG)

Diffuse intrinsic pontine glioma (DIPG) is a horrific childhood brain cancer. Patients die within 2 years of diagnosis. Treatments include radio- and chemotherapy, however the tumor always regrows due to resistance of the tumor cells to therapy. Understanding and tackling resistance is key to improve survival of patients with DIPG. We ...

Preclinical Investigation Toward a Clinical Trial of Combination, Multimodality Treatment ...

DIPG is an aggressive childhood brain tumor that is nearly always fatal. Although most past patients have died of the tumor pushing on the brainstem’s pons area, DIPG spreads to other parts of the brain and spinal cord, known as the central nervous system (CNS). To cure DIPG, ...

Targeting Glycolysis for Inhibition of Tumor Growth in Pediatric Brain ...

Pediatric brain tumors have limited responses to conventional therapeutic option and high mortality rates. Novel approaches to treat these and other forms of cancer involve targeting metabolic mechanisms of cancer cells from which they derive energy. These include aerobic glycolysis or the Warburg effect; named after Otto Warburg who first ...

A novel CRISPR/Cas9 approach to target the EWS-FLI1 fusion ...

Ewing’s sarcoma (EWS) is a devastating pediatric cancer of bone and soft tissues where the treatments used are typically very toxic, resulting in profound morbidities. Furthermore, these intense and non-specific treatments often lead to secondary tumors later in life. Thus, a less toxic and more specific treatment is ...