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Results: 13

Precision Therapy to Overcome Chemoresistance in Pediatric Glioblastoma

Glioblastoma (GBM) remains one of the most aggressive and lethal forms of cancer. Despite the best available treatment options including surgical resection, radiotherapy, and chemotherapy, prognosis is poor in glioblastoma, with a median overall survival of 14 months.1Currently, temozolomide (TMZ) is the preferred chemotherapeutic drug in the treatment of GBM ...

The current situation of childhood brain tumor long-term survivors in ...

Central nervous system tumors, represent the highest mortality rate of all childhood malignancies, Nevertheless, the number of survivors of pediatric Brain tumors continues to increase. Gradually improving survival rates and a growing population of long-term survivors have expanded the focus of research, Increased attention has been given to late ...

Targeting Glycolysis for Inhibition of Tumor Growth in Pediatric Brain ...

Pediatric brain tumors have limited responses to conventional therapeutic option and high mortality rates. Novel approaches to treat these and other forms of cancer involve targeting metabolic mechanisms of cancer cells from which they derive energy. These include aerobic glycolysis or the Warburg effect; named after Otto Warburg who first ...

Diffuse Intrinsic Pontine Glioma.

In tumors like DIPG, the diagnosis itself spells a death sentence for the child affected. For several decades, none of the altered fractionation radiotherapy or additional chemotherapy or targeted agents have shown a significant benefit over conventional radiotherapy. We propose amalgamation of several known and tested hypothesis in DIPG ...

COllaborative Network for NEurooncology Clinical Trials (CONNECT)

CONNECT’s goal is to establish an international clinical trials collaboration for the conduct of scientificallrational, pilot studies to assess feasibility and early efficacy of incorporating promising novel agents testablished frontline therapeutic regimens in children with newly-diagnosed, high-risk brain tumors. Thicollaboration builds on the existing infrastructure and partnerships established ...