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Results: 269

Development of subgroup-specific models of paediatric DIPG

 Brain tumors are the largest group of solid tumors and the leading cause of cancer-related deaths in childhood1. The most devastating of these is DIPG, an incurable brainstem tumor with a median survival of less than one year2,3. DIPGs show poor response to conventional radiation and chemotherapeutic strategies used ...

Investigating mechanisms of therapeutic resistance in DIPG

Brain tumors are the largest group of solid tumors and the leading cause of cancer-related deaths in childhood1. The most devastating of these is DIPG, an incurable tumor with a median survival of less than one year2,3.  DIPGs show poor response to conventional therapy and until recently we have ...

Ultrasound-induced delivery of Panobinostat in preclinical models

Brain tumors are the leading cause of mortality and morbidity from cancer in children and young adults. Malignant gliomas, including supra9tentorial high grade gliomas (HGG) and Diffuse Intrinsic Pontine Gliomas (DIPG), remain a major therapeutic challenge in pediatric oncology because they are still incurable. The failure of current treatments ...

The evolutionary dynamics of diffuse intrinsic pontine glioma

Diffuse intrinsic pontine glioma are high grade glial tumours arising in the brainstem with a median survival of 9-12 months, and a distinct biology compared to similar looking tumours arising in the cerebral hemispheres in children and adults. A major challenge to improve outcomes for these tumours is their extensive ...

THE EVOLUTIONARY DYNAMICS OF DIFFUSE INTRINSIC PONTINE GLIOMA

Diffuse intrinsic pontine glioma are high grade glial tumours arising in the brainstem with a median survival of 9-12 months, and a distinct biology compared to similar looking tumours arising in the cerebral hemispheres in children and adults. A major challenge to improve outcomes for these tumours is their extensive ...

Establishment of an International Diffuse Intrinsic Pontine Glioma Registry (DIPG ...

Brainstem gliomas account for up to 20% of all CNS tumors in children with a median age at presentation of 6-7 years.1  Diffuse intrinsic pontine gliomas (DIPG) comprise 80% of all brainstem gliomas. In North America and Europe, approximately 300 children develop brainstem gliomas per year. 2 Prognosis for patients with DIPGs remains ...