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Results: 269

CURING DIFFUSE MIDLINE GLIOMA: ALL IT TAKES IS ONE GOOD ...

Diffuse Midline Gliomas (DMG) are one of the deadliest childhood brain cancers, with no effective treatments and universally fatal outcomes. While scientific understanding of DMG has improved dramatically over the past decade, these advances haven’t translated into real-world therapies. Too often, research gets stuck testing ideas in the ...

Precision Immunotherapy for Diffuse Midline Glioma Targeting

Diffuse midline gliomas (DMG)/diffuse intrinsic pontine glioma (DIPG) are aggressive brain tumors that occur in children. These tumors are currently incurable, and new, more effective treatments are urgently needed. This project proposes a new strategy to tackle DIPG using cutting-edge precision immunotherapy and radiation therapy approaches, tested in lab ...

THYROID HORMONE THERAPY IN COMBINATION WITH CHEMOTHERAPY FOR PEDIATRIC MEDULLOBLASTOMA

Medulloblastoma is the most common malignant brain tumor in children. While initial treatments are often effective, options for cure after relapse remain limited. Our work has shown that medulloblastoma cells are highly sensitive to T3, the active form of thyroid hormone. in both cell lines and mouse models ...

Advancing T cell therapy for DMG using tumor-directed gamma delta ...

We propose a new type of immunotherapy for diffuse midline glioma (DMG) and using gdT cells, a type of T cell that targets cancers differently than the T cells previously used in brain tumor immunotherapies, and using a novel immune-stimulating drug that we developed. Children with DMG need new ...

Multilamellar H3K27M RNA aggregates targeting diffuse midline glioma

   Diffuse midline gliomas (DMGs) are some of the worst childhood cancers, typically marked by an H3K27M mutation, which is an excellent target as it is expressed by nearly all the tumor cells.    We have designed a way to repetitively layer H3K27M attack &...

A Phase 1a Open-label Study Evaluating the Safety of 177Lu-DTPA-omburtamab ...

DMG is a rare but aggressive brain tumor that primarily affects children. Despite advances in cancer treatment, DMG remains universally fatal, with most children surviving less than a year after diagnosis. One major challenge is that most drugs can't reach the tumor because of the brain’s natural ...