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Results: 269

Novel tumor rejection antigens against DIPG and DMG for adoptive ...

LAY SUMMARY Brain cancers are the number one cause of cancer-related death in children. Major challenges in the development of therapeutics include the lack of reliable targetable antigens, the tumor heterogeneity, and the highly immunosuppressive tumor microenvironment. Our group has pioneered a novel adoptive cellular therapy platform that bypasses these ...

Phase 1 study of ATM kinase inhibitor AZD1390 in recurrent pediatric ...

Choroid plexus carcinomas (CPCs) are highly malignant brain tumors diagnosed primarily in children less than four years of age, of whom about two-thirds will die within five years of diagnosis using current therapies. There are currently no available treatment trials specific for either newly diagnosed or recurrent CPC. Moreover, the ...

A Phase 1/2 Study Evaluating the Safety and Efficacy of 177Lu-omburtamab ...

DMG is a rare but aggressive brain tumor that primarily affects children. Despite advances in cancer treatment, DMG remains universally fatal, with most children surviving less than a year after diagnosis. One major challenge is that most drugs can't reach the tumor because of the brain’s natural ...

Enhancing the recruitment of tumor infiltrating lymphocytes to improve responses ...

ABSTRACT Diffuse midline glioma (DMG) including those within the pons (diffuse intrinsic pontine glioma [DIPG]) is the most lethal form of childhood cancer with a median overall survival of 9-11 months, and a 5-year survival <1%. DMG represents 20% of all pediatric cancer deaths, with no recognized treatments other than radiotherapy, ...

Targeting regulators of ribosome biogenesis as a new therapeutic option ...

Ribosome biogenesis, the generation of mature ribosomes, has been established as a cancer vulnerability, as malignant cells require increased and specialized protein production to sustain their growth. Ribosomal RNA (rRNA), a critical component of the ribosome, undergoes chemical modifications essential for ribosome assembly and function. Small nucleolar RNAs (...

Translating a novel immunomodulatory virus to clinical practice for pediatric ...

Diffuse midline gliomas (DMGs) are aggressive pediatric brain tumors with a poor prognosis, as most patients survive less than 12 months after diagnosis. Current treatments, such as radiation and chemotherapy, are largely ineffective because these tumors create a protective environment that blocks the immune system and limits drug delivery. Our project ...