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Results: 269

Targeted and Tuned: GPNMB/B7H3 Dual-Targeting CAR T Cells ...

Children diagnosed with diffuse midline glioma, a devastating brain cancer, face heartbreaking odds. Radiation, the only current treatment, offers just a little more time and often causes serious, lifelong side effects. Our mission is to create safer, more effective therapies that give children a real chance to survive and thrive. ...

Dietary Methionine Restriction in Combination With ONC201 in Pediatric and ...

Tumors of the central nervous system (CNS) are the leading cause of cancer-related death in children. Diffuse midline gliomas (DMGs) are the most aggressive tumors in children, with an average survival of 9-12 months. Despite decades of research, there are no improvements in outcomes. Most DMGs have an alteration in ...

Targeting DMG microenvironment with LSD1 Inhibitors

Diffuse Midline Gliomas or DMGs are a type of brain cancer that primarily arise in children and are incurable.  This proposal will evaluate a novel therapy for DMG that targets an enzyme called LSD1.  We chose to focus on LSD1 as we have preliminary data that LSD1 turns ...

Eliminating DIPG/DMG carrying histone H3 mutations using repurposed drugs

Brain cancers are the leading cause of cancer deaths in children, with pediatric High-Grade Gliomas (pHGG) such as Diffuse Intrinsic Pontine Gliomas (DIPG) and Diffuse Midline Gliomas (DMG) lacking therapies and resulting in 100% fatality within months of diagnosis. The vast majority of DIPG and DMG carry mutations in a protein ...

Curing Diffuse Midline Glioma: all it takes is one good ...

Diffuse Midline Gliomas (DMG) are one of the deadliest childhood brain cancers, with no effective treatments and universally fatal outcomes. While scientific understanding of DMG has improved dramatically over the past decade, these advances haven’t translated into real-world therapies. Too often, research gets stuck testing ideas in the ...

Thyroid hormone therapy in combination with chemotherapy for pediatric medulloblastoma

Medulloblastoma is the most common malignant brain tumor in children. While initial treatments are often effective, options for cure after relapse remain limited. Our work has shown that medulloblastoma cells are highly sensitive to T3, the active form of thyroid hormone. n both cell lines and mouse models, ...