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Results: 269

Bridging the Gap: Developing UNIpath-Ped, A Digital Pathology Foundation Model ...

Artificial intelligence is rapidly transforming how we diagnose and understand cancer. By analyzing digital images of tissue samples, AI can help doctors identify cancer types, predict potential for metastasis, and choose better treatments. These breakthroughs have been especially successful in adult cancers, using AI systems trained on hundreds of thousands ...

Imaging of DMG Stem Cells using Mannose-Weighted CEST MRI

Aggressive brain tumors contain cancer stem cells that drive tumor aggressiveness and recurrence but remain elusive to detect. We have found that they acquire an abnormal sugar coating when they transition from a less aggressive to a more aggressive type. At Johns Hopkins, we have recently developed a specialized magnetic ...

Leveraging zebrafish models of diffuse midline glioma to identify new ...

Radiation therapy is the only treatment that works for DMG, but it only works for a short time. There is a new type of radiation called FLASH that kills tumor cells but spares normal tissues. We need to understand how FLASH radiation might work in DMG. Thanks to funding from ...

Uncovering and Exploiting Tumor Vulnerabilities in Pediatric Medulloblastoma via Integrated ...

Brain tumors are the leading cause of cancer-related deaths in children. Many children do not respond well to standard treatments, and often suffer severe long-term side effects. In adult cancers, we found that some tumors have specific weaknesses, that can make them more sensitive to certain drugs. Unfortunately, these genetic ...

ALKBH5 as a novel therapeutic target for treating medulloblastoma

Medulloblastoma is the most common and aggressive brain cancer in young children. Even with current treatments, many kids with high-risk forms of this cancer do not survive more than five years, and the disease often returns within two years. Those who do survive often experience serious and long-lasting side effects ...

Enhancing CAR-NK cell therapy against human pediatric diffuse intrinsic pontine ...

DIPG is a deadly childhood brain cancer that urgently needs new treatments. CAR-T cell therapy, which uses genetically engineered immune cells to have a tumor-specific handshake to kill cancer, has shown promise but is expensive, difficult to produce, and can cause severe side effects. A newer alternative, CAR-NK cell therapy, ...