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Results: 269

Connexins in Diffuse Midline Gliomas

Diffuse Midline Gliomas (DMG), including Diffuse Intrinsic Pontine Gliomas, are among the most aggressive and devastating brain tumors affecting children. Unfortunately, current treatments rarely result in a cure. Our research has identified a potentially groundbreaking target for more effective therapy: a group of proteins called connexins, which are produced in ...

Oncogenic Role of PRC2 Macromolecular Compartmentalization in DIPG

Diffuse interstitial pontine glioma (DIPG) is an aggressive pediatric brain tumor with a devastating prognosis. Over 97% of children die within five years of diagnosis, and there is currently no treatment targeting the biological causes of DIPG. Almost all children with DIPG develop a mutation in a protein called histone H3, ...

Intranasal Delivery of Oncolytic Virus in DMG

Pediatric high-grade gliomas are one of the most common causes of cancer-related death in children, and diffuse midline gliomas (DMGs) are the most rapidly fatal of these tumors. The infiltrative nature together with delicate tumor location in the brainstem precludes surgical resection, and the blood-brain barrier (BBB) prevents to deliver ...

Rewiring RNA: Targeting m6A-YTHDF Axis to Treat High-Risk Neuroblastoma

High-risk neuroblastoma, particularly tumors with MYCN amplification, remains one of the most challenging pediatric cancers to treat, with limited targeted therapies and a high rate of relapse. These aggressive tumors evade treatment by blocking cell differentiation and degrading RNA molecules that would normally produce proteins suppressing tumor growth. Our ...

Binary Nose-to-Brain Drug Delivery for Targeted DIPG/DMG Treatment

Diffuse intrinsic pontine glioma (DIPG) is a devastating pediatric brain tumor with dismal prognosis. Despite the best treatment efforts, the average survival of afflicted children is about one year. Quite clearly, there is an urgent medical need for better treatments. The general treatment of DIPG involves radiation and chemotherapy. However, ...

Targeting DIPG through Therapeutic Dietary Intervention

DIPG remains a highly lethal disease with no effective treatment options. How DIPG cells reprogram nutrient consumption and usage via metabolic pathways to sustain their growth is not well understood. Using profiling of metabolites, we uncovered DIPG cells elevate the consumption and breakdown of branched chain amino acids (BCAAs); leucine, ...