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Results: 269

Enabling epigenetic therapies by exploring DIPG chromatin sensitivities

Background: Recently, driver mutations in histone H3 have been found to correlate with particularly malignant forms of DIPG. These mutations change lysine 27 of H3 to methionine (K27M), abrogating methylation and acetylation at this site, both of which are epigenetic marks that influence chromatin architecture and are important for regulating ...

Characterizing resistance mechanisms to radiation therapy and adjuvant chemotherapy in ...

Children diagnosed with Diffuse Intrinsic Pontine Gliomas (DIPGs) face a dismal prognosis, with rampant progression after initial therapy with chemoradiation and a median survival of less than two years. These tumors are universally fatal, with tumors rapidly exhibiting resistance to the current treatments. Therapeutic strategies that delay or ablate the ...

An early Phase 2 Study of LEE011, a CDK4/6 Inhibitor, following ...

Background: The prognosis for diffuse intrinsic pontine gliomas (DIPG) remains dismal. Although radiotherapy can extend survival by 2-3 months, no adjuvant therapy has proven effective, despite the numerous trials conducted in the past 4 decades.  Similarly, high-grade gliomas (HGG), particularly those which are not resectable and/or are Grade IV, ...

Intra-tumoral heterogeneity in diffuse intrinsic pontine and midline high-grade gliomas

Background: Diffuse intrinsic pontine glioma (DIPG) is a lethal pediatric brain tumor that affects approximately 150 children in North America each year.1 Though radiation therapy can prolong survival by 2-3 months, adjuvant chemotherapy has not improved outcome. The median survival is less than 12 months and has remained unchanged for the last 30 ...

MRI Guided Focused Ultrasound: Towards Clinical Translation in Diffuse Intrinsic ...

Diffuse    Intrinsic    Pontine    Glioma    (DIPG)    is    a    devastating    tumour    that    occurs    predominantly    in &...

Defining the cellular archetecture of diffuse intrinsic pontine glioma through ...

Single-cell genomic profiling is revolutionizing our understanding of tumor biology, as it enables for the first time a genome-wide interrogation of tumor programs at cellular resolution, offering unprecedented insights into tumor cells and their micro-environment at a depth that was unthinkable even a few years ago. I expect that defining ...