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Results: 269

Augmentation of the tumor immune microenvironment to enhance B7-H3 ...

Diffuse midline glioma (DMG) is an aggressive, incurable pediatric brain tumor requiring new therapies. CAR T cells are a targeted immunotherapy in which some of a patient’s white blood cells are removed, engineered to fight a specific cancer target, and then returned to seek out the tumor. Seattle ...

Proinflammatory Myeloid Cells with GD2.CAR as Immunotherapy for High ...

High grade gliomas (HGG), including Diffuse Midline Gliomas (DMG), are highly aggressive brain cancers, with less than 5% survival at five years. DMGs are predominantly seen in children and young adults This proposal seeks to develop a novel immunotherapy to benefit these patients. Myeloid cells are white blood cells that are ...

Engineering Suppression-Resistant CAR-T Cells for the Treatment of Pediatric DIPG ...

Diffuse Intrinsic Pontine Glioma (DIPG) is an aggressive and fatal brain tumor that affects young children. Because it grows in the brainstem, it cannot be removed with surgery, and radiation offers only temporary relief. Chemotherapy and other standard treatments have not been effective. Most children with DIPG survive less than ...

Reprogramming the tumor immune landscape: combined use of NK cells ...

Medulloblastoma is the most common malignant brain tumor in children. For children diagnosed with high-risk medulloblastoma, treatment often includes aggressive radiation therapy. Even worse, many children still experience relapse, and current treatments are not enough to save all of them. This project aims to better understand how radiation affects ...

Targeting Alternatively Activated Macrophages in Diffuse Midline Glioma

Diffuse midline glioma (DMG) is a currently incurable childhood tumor that arises in the midline or brainstem of the brain. There are likely several reasons why treatments fail in these tumors; our research is focused on macrophages, which normally assist the body in fighting off disease and illness but are ...

MONITORING NANOBODY-BASED B7H3 CAR-T CELL BEHAVIOR AND EFFICACY IN ...

Diffuse intrinsic pontine glioma (DIPG) or midline glioma (DMG) are highly aggressive brain tumors and the leading cause of cancer related death in children. These tumors often cannot be surgically removed and to date, treatment with several types of chemotherapy has not been effective. As radiotherapy, the other cornerstone of ...