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Results: 269

Determine the efficacy of BMP and MEK inhibitors with RT ...

We and others co-discovered the presence of activating mutations in ACVR1 in 25% of human DIPGs in 2014. Subsequently, my laboratory has developed a murine DIPG model incorporating R206H ACVR1 and observed that R206H ACVR1 significantly accelerates brainstem gliomagenesis. In addition, short-term treatment with a bone morphogenetic protein pathway inhibitor (...

Teaching the Immune System to Fight DIPG: In Vivo Vaccination, ...

This project aims to develop better, faster, and more accessible immunotherapies for treating Diffuse Intrinsic Pontine Glioma (DIPG), a devastating childhood brain cancer. The strategy focuses on targeting a marker found on DIPG cells called GD2, which can help the immune system recognize and attack the tumor. We will first ...

H3K27M-directed multilamellar RNA nanoparticle aggregates: a novel scaffold ...

Diffuse midline gliomas (DMGs) are some of the worst childhood cancers, typically marked by an H3K27M mutation, which is a perfect immune target as it is expressed by nearly all the tumor cells. We have designed a way to repetitively layer H3K27M attack ‘orders’ ...

Precision Immunotherapy for Diffuse Midline Glioma Targeting

Diffuse midline gliomas (DMG) or diffuse intrinsic pontine gliomas (DIPG) are aggressive brain tumors that occur in children. These tumors are currently incurable, and new, more effective treatments are urgently needed. This project proposes a new strategy to tackle DIPG using cutting-edge precision immunotherapy and radiation therapy approaches, tested in ...

Developing tumor-directed gamma delta T cell therapy for DMG, with ...

We propose a new type of immunotherapy for diffuse midline glioma (DMG) and using gdT cells, a type of T cell that targets cancers differently than the T cells previously used in brain tumor immunotherapies, and using a novel immune-stimulating drug that we developed. Children with DMG need new therapies ...

A Diffuse Midline Glioma Combination/Multimodality Clinical Trial and Investigation

In this project, we will bring a paradigm-shifting treatment approach, which has led to cures of other previously incurable childhood cancers, to diffuse midline glioma (DMG) for the first time: combination, multimodality therapy. Our clinical trial will incorporate radiation, locally delivered chemotherapy directly to the tumor, systemic chemotherapy to the ...