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Results: 269

Targeting lactate production pathways as a novel therapy against DIPG

Cancer cells secrete lactic acid, creating an inhospitable glucose-poor and lactate-rich tumor environment that would otherwise be lethal to most cells. Recent advances trying to understand DIPG development demonstrated that lactic acid was three times higher in DIPG cells. Furthermore, our laboratory found that the enzyme which makes the lactic ...

The LEVI'S-CATCH Study: Continuing third-generation GD2-CAR-T cell therapy for ...

Diffuse midline glioma (DMG) is not curable and fewer than 2% of patients survive 5 years. Many experimental drugs have been tried and few have made any impact on the disease. Chimeric Antigen Receptor (CAR)-T cell therapy is a new, promising treatment being developed in several international centers for DMG patients. ...

An AI-driven integrated risk score for improving survival outcomes in ...

This project focuses on developing a non-invasive AI-driven integrated risk score for improving survival outcomes in pediatric Medulloblastoma (MB). MB is the most frequent malignant brain tumor in children, accounting for 20% of pediatric intracranial tumors, and the 5-year survival rate is 60-80%.  Relapse in MB is nearly fatal, making ...

Multilamellar H3K27M RNA aggregates targeting diffuse midline glioma, ...

Diffuse intrinsic pontine glioma/midline gliomas (DIPG/DMG) are fatal brain cancers in desperate need of new treatments, and while immunotherapy has held intriguing promise, thus far its potential has not been fully realized. Messenger RNA, the messages that communicate instructions from DNA to the rest of the cell, have&...

THE THERAPEUTIC KETOGENIC DIET FOR THE ADJUVANT TREATMENT OF DIPG

Diffuse Intrinsic Pontine Glioma (DIPG) is a highly infiltrative pediatric tumor with median survival of ~9 months. Radiation is the standard of care; however, this provides only short term benefits and to date, other therapy trials have shown relatively little success and/or unacceptable side effects. This has led parents and ...

Harnessing developmental neurobiology to reprogram the cell of origin of ...

Transcription factors can be considered as “molecular switches” that can turn ON or OFF specific sets of genes. The overall objective of this project is to understand how the gene networks up- and downstream of the transcription factor DLX2, and how changes to DLX2 itself, affect brain and ...