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Results: 269

Identify molecular features of Richter syndrome by single-cell transcriptome and 3...

Abstract: Our research project aims to explore the mysterious changes that occur in a type of blood cancer called Richter Syndrome (RS). RS is what happens when a slow-growing leukemia, known as chronic lymphocytic leukemia (CLL), suddenly transforms into a much more aggressive form of lymphoma. This transformation is difficult ...

Targeting Diffuse Midline Glioma vulnerabilities as a therapeutic strategy

Diffuse Midline Gliomas (DMGs), including Diffuse Intrinsic Pontine Gliomas (DIPGs), are among the most aggressive pediatric brain tumors and the leading source of mortality in pediatric oncology. The median life expectancy of these children remains below 14 months after diagnosis, and nearly none survive beyond the second year. All therapeutic approaches ...

Discovery of new therapies for Diffuse intrinsic pontine glioma (DIPG) ...

Diffuse intrinsic pontine glioma (DIPG) is the most lethal brain tumor in children, with a survival time of only 9-11 months. Despite many years of research, there is still no cure for DIPG, highlighting the urgent need for new treatments. Circular RNAs (circRNAs) are a new type of RNA that ...

Investigation of The firSt blood-brain barrier penetrant hUman DHODH iNhibitors ...

Diffuse midline glioma (DMG) is a highly aggressive tumor that usually occurs in children aged 5-10 years. DMG accounts for more than 15 % of all pediatric brain tumors and is the leading cause of cancer-related deaths in children. In Europe, about two children per 100,000 are affected each year, which means about 100...

Understanding tumor heterogeneity and characterizing treatment responses in ACVR1-mutated ...

Diffuse midline gliomas (DMGs), sometimes called diffuse intrinsic pontine gliomas (DIPGs) are aggressive brain tumors that occur in children. There is currently no cure for these cancers. DMGs occur because genetic defects appear in some cells in the brain during childhood. Researchers and doctors have identified many of these genetic ...

Unravelling transcriptional plasticity as a non-genetic mechanism of drug resistance ...

Diffuse midline glioma (DMG) is a malignant brain tumour arising in children representing a major unmet clinical need, with a 2-year survival rate close to zero. We and others have found that some DMGs have alterations in the MAPK pathway which drives cell growth – drugs targeting this pathway may ...