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Results: 269

SUMOylation as a novel therapeutic target in DIPG

Post-translational protein modification (PTM) is one of the important  mechanisms by which the function of cellular proteins are modulated.  SUMOylation is a  reversible PTM which has emerged as a crucial molecular  mechanism, involved in the control of DNA damage repair, immune responses, carcinogenesis, cell  division ...

TARGETING METABOLIC VULNERABILITIES FOR TREATING MEDULLOBLASTOMA

Abstract Medulloblastoma (MB) is the most common malignant childhood brain tumor that accounts for a significant number of all pediatric cancer-related deaths. MB malignancy, recurrence, and therapy resistance have been attributed to Medulloblastoma Stem Cells (MBSCs) that self-renew and evade apoptosis. These facts underline the importance of identifying new drivers/...

CXCR1/2 Signaling Pathway: a role in the invasive mechanism of ...

High-grade gliomas (HGGs) make up 8-10% of children's brain tumors and are often fatal within two years. These tumors can develop in the cerebral cortex or infratentorial regions like the brainstem. About half of pediatric HGGs occur in midline locations such as the pons, known as diffuse midline gliomas (...

A NOVEL FORMULATION TO ALLOW THE SIMULTANEOUS TARGETING OF MYC ...

Diffuse Intrinsic Pontine Glioma (DIPG) is a devastating brain cancer that primarily affects children between the ages of 5 and 10. With a poor prognosis, most children diagnosed with DIPG survive only about 9 to 12 months. Current treatments like radiation therapy offer only temporary relief, leaving families and doctors in desperate need of ...

Safety and efficacy of intraventricular infusion of B7H3 with ...

We are exploring a new treatment for Diffuse Intrinsic Pontine Glioma (DIPG), a very aggressive type of brain tumor that occurs in children. This type of tumor is particularly challenging because it grows quickly and is difficult to treat, leading to poor outcomes with the limited treatment options currently available. ...

Unlocking the potential of the blood-brain barrier in the fight ...

Despite considerable research efforts, brain tumours persist as the leading cause of death among children. A significant obstacle in treating these tumours is the blood-brain barrier (BBB), a protective barrier surrounding the brain that typically restricts the passage of therapeutic agents. Of particular concern is Diffuse Midline Glioma (DMG), a ...