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Results: 269

Developing the next generation of targeted epigenetic therapy in diffuse ...

Diffuse intrinsic pontine glioma (DIPG) is a tumour of the brainstem and is recognized as one of the most lethal of all cancers. Every year, about 150-300 children in the USA and 3,000 children worldwide are diagnosed with DIPG. The prognosis of DIPG is devastating as only 10% of the patients ...

TRANSLATING MECHANISM TO PATIENT BENEFIT FOR ACVR1-MUTANT DIFFUSE INTRINSIC ...

Diffuse intrinsic pontine glioma, or DIPG, is a childhood brain tumor occuring in the brainstem of young children, for which there is currently no cure. Until recently, little was known about the makeup of this type of cancer, and treatments used for other adult brain tumor types consistently failed. Through ...

Characterizing and Targeting ABL1 and ABL2 in Medulloblastoma Leptomeningeal Dissemination

The molecular mechanisms that drive dissemination throughout the central nervous system (leptomeningeal dissemination) in patients with medulloblastoma (MB) are not well characterized, resulting in a nearly 100% mortality in children with recurrent leptomeningeal MB. Additionally, the presence of LD at diagnosis of MB, the most common malignant pediatric brain tumor, is ...

CD200 Activation Receptor Ligand (CD200AR-L) and Allogeneic Tumor Lysate ...

This is a multi-center Phase I study of a new adjuvant CD200 activation receptor ligand (CD200AR-L) in combination with imiquimod and the GBM6- AD brain tumor vaccine to treat newly diagnosed diffuse midline glioma malignant glioma and recurrent high grade glioma in Children. The Olin lab ...

The therapeutic ketogenic diet for the adjuvant treatment of DIPG

Diffuse Intrinsic Pontine Glioma (DIPG) is a highly infiltrative pediatric tumor with a median survival of ~9 months. Radiation is the standard of care; however, this provides only short term benefits and to date, other therapy trials have shown relatively little success and/or unacceptable side effects. This has led parents ...

(2023) Enhancing the recruitment of tumor infiltrating lymphocytes to improve responses ...

ABSTRACT Diffuse midline glioma (DMG) including those within the pons (diffuse intrinsic pontine glioma [DIPG]) is the most lethal form of childhood cancer with a median overall survival of 9-11 months, and a 5-year survival <1%. DMG represents 20% of all pediatric cancer deaths, with no recognized treatments other than radiotherapy, ...