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Results: 269

CSF Cell-free Tumor DNA (CSF cfDNA) Liquid Biopsies for Pediatric, ...

Pediatric brain tumors are the leading cause of cancer-related death in children and adolescents [1]. Recent advances in molecular analysis have led to major improvements in diagnostic accuracy and prognostication for pediatric patients with brain tumors, allowing physicians to adapt available therapies to specific patient’s needs[2-4]. However, access ...

Targeting alpha-KG synthesis for the therapeutic intervention in DIPG

Diffuse intrinsic pontine glioma (DIPG) is an aggressive childhood brain tumor, accounting for 10% of all pediatric central nervous system tumors with the median overall survival of 10.5 months. Since DIPG tumors infiltrate brainstem and pons, they are inoperable because surgery in this location of the brain can lead into severe neurological ...

Comprehensive characterization of secreted RNA from Diffuse Midline Glioma (DMG)

Diffuse Midline Gliomas (DMG) are fatal childhood brain cancers. Current methods to diagnose and monitor DMG include brain imaging and biopsies; both of these approaches have limitations, and a non-invasive assay for DMG is critically needed. Exosomes are vesicles, secreted by cells, into bodily fluids, such as blood. These vesicles ...

Use of Artificial Intelligence-powered Müller Matrix Polarimetry to transform ...

This multidisciplinary project will investigate ways to improve management of pancreas cancer patients, by developing an analysis method called Müller Matrix Polarimetry (MMP) to diagnose cancers with greater detail. MMP distinguishes healthy and cancer cells by the way light is reflected differently by these tissues. Using MMP together ...

Targeting post-translational protein modification to halt Diffuse Intrinsic Pontine Glioma ...

Diffuse intrinsic pontine gliomas (DIPG) are a devastating childhood brain cancer which are universally fatal. Currently DIPG remain incurable as no therapy has been developed that can target underlying processes involved in the pathogenesis of this disease. While key driver mutation have been identified (such as histone mutations), ...

Preclinical evaluation of TP-0184 in an autochthonous mouse model of ...

Evaluation of new cancer drugs, and determining which models best predict whether the new cancer drug will benefit children with DMG/DIPG is unclear.   DMG/DIPG tumor cells have complex interactions with cell types normally found in the brain. Therefore, new therapies must be evaluated in animal models ...