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Results: 269

PBTC-058: Phase 2 Study of Intraventricular Omburtamab-based Radioimmunotherapy for Pediatric Patients ...

Medulloblastoma is the second most common malignant brain tumor of childhood. Treatment consists of a combined-modality approach including surgery, radiotherapy and chemotherapy in most patients. Medulloblastoma relapse (rMB) occurs in approximately 30% of patients, is universally fatal and accounts for 10% of all childhood cancer deaths. Thus, there is ...

Assessing the potential of the HDAC inhibitor givinostat ± radiotherapy for ...

Pediatric brain tumors are the most frequent childhood solid tumors, and the leading cause of cancer related death in children. Patients with a diffuse intrinsic pontine glioma (DIPG) or midline glioma (DMG) – located in the brainstem, thalamus, or spinal cord – have a particularly bad prognosis. These tumors often ...

Preclinical assessment of efficacy and specificity of logic-gated CAR-T cell ...

Proposal Abstract: Chimeric Antigen Receptor (CAR)-T cells have been clinically effective in patients with leukemias and lymphomas. Our goal is to bring similar success in treating a fatal brain tumor in children called DIPG (Diffuse Intrinsic Pontine Glioma). A major obstacle in treating brain tumors with CAR-T cell therapy ...

A novel formulation to allow the simultaneous targeting of MYCN ...

Introduction: The aim of this proposal is to develop potential treatments for Diffuse Intrinsic Pontine Glioma (DIPG), a highly aggressive brain tumour primarily affecting pediatric patients. DIPG remains a significant challenge in the medical field, with limited treatment options and poor survival rates. To address this critical issue, we have ...

Dual targeting processive transcription for Myc-driven circuitry in medulloblastoma

Medulloblastomas (MB) are the most common brain cancer in children.  The highest-risk subgroups are defined by elevated expression of a protein called Myc (Myc-MB) and exhibit high rates of metastasis and disease recurrence, resulting in unacceptable long-term survival rates of less than 30%. The Myc protein itself has proven ...

Starve the monster: Investigation of multi-metabolic treatment strategies for H3.3...

Diffuse midline glioma (DMG) including diffuse intrinsic pontine glioma (DIPG) are most aggressive, deadly brain tumors of childhood with marked therapeutic resistance. DIPG/DMG are uniquely characterized by a histone mutation (H3K27M) that significantly contributes to the poor prognosis. In consequence, targeting H3K27M-mutation in DIPG/DMG ...