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Results: 269

Mapping DIPG Tumour Progression and understanding Biological Heterogeneity using Spatial ...

Diffuse Intrinsic Pontine Glioma (DIPG) otherwise known as Diffuse Midline Glioma (DMG) is a fatal brain stem glioma arising in young children. There are no effective therapies for DIPG and children typically succumb to the disease within 2 years. No therapy to-date has improved the survival rate for children with DIPG ...

Exploiting 3D Tumor Tissue Analogs to Elucidate the Role of ...

Diffuse intrinsic pontine glioma (DIPG) is a rare form of inoperable cancer arising in the brainstem of children, with poor response to chemotherapy and no improvement in outcomes over the past 3 decades. The unique brainstem location and the invasive nature of DIPG is suboptimally represented in modern therapeutic models and ...

Exploring Novel Targets In DIPG

     Diffuse intrinsic pontine glioma (DIPG) that represents up to 85% of brainstem tumors is a rare, infiltrative, and incurable brainstem malignancy in children resulting in death within one year from diagnosis (1-5).   To find new drug targets for DIPG, we recently performed the first analysis ...

Starve the monster: Multi-metabolic treatment strategies for H3.3K27M-mutant ...

Diffuse midline glioma (DMG) including diffuse intrinsic pontine glioma (DIPG) are most aggressive, deadly brain tumors of childhood due with marked therapeutic resistance. DIPG/DMG are uniquely characterized by a histone mutation (H3K27M) that significantly contributes to the poor prognosis. In consequence, targeting H3K27M-mutation in DIPG/...

Treatment of Diffuse Intrinsic Pontine Glioma with the Oncolytic Zika ...

Diffuse intrinsic pontine glioma (DIPG) is a devastating brainstem tumor affecting 150-300 children in the US per year. The overall rate of survival is dismal, with only 10% of children surviving beyond the second year from the time of diagnosis.[1]  Though a rare tumor with high mortality, DIPG represents 80% of ...

Targeting macrophages to improve the survival of DIPG

Diffuse Intrinsic Pontine Glioma (DIPG) is a type of high-grade pediatric glioma (pHGG) that remains uniformly fatal in 2020, represents the leading cause of death for pediatric brain tumor patients, and for which the standard of care has not improved in over 50 years. Improvements in outcomes require the identification of ...