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Results: 269

Synthetic lethality screening with methionine restriction for treatment of DIPG

DIPG is incurable cancer that is the number one cause of cancer-related deaths in children. DIPG is hard to treat because of the surgically inaccessible location, blood-brain barrier which limits some therapies and toxicity considerations related to the young age of DIPG patients. We have focused our efforts on finding ...

Epigenetic Regulation of Cell Fate Reprogramming in H3K27M-altered ...

Diffuse midline glioma, including those located at the pons in the brainstem (diffuse intrinsic pontine gliomas, DIPGs) are childhood brain tumors and patients with DIPG have a poor prognosis with a median survival time less than 1 year from diagnosis. Currently, apart from radiation therapy, which partially slows down tumor growth, ...

Phase 2 Study of Systemic IL-6 Receptor Antagonist ACTEMRA® (tocilizumab) for ...

This proposal is designed to help support a novel international clinical trial for children with the highly morbid brain tumor, Adamantinomatous Craniopharyngioma (ACP).  ACP is a solid/cystic tumor that originates in the sellar/suprasellar region at the base of the brain, adjacent to critical structures for vision, hormone ...

Phase 2 Study of the MEK inhibitor MEKTOVI® (binimetinib) for the ...

This proposal is designed to help support a novel international clinical trial for children with the highly morbid brain tumor, Adamantinomatous Craniopharyngioma (ACP).  ACP is a solid/cystic tumor that originates in the sellar/suprasellar region at the base of the brain, adjacent to critical structures for vision, hormone ...

A Phase 1/2 Study of Sonodynamic Therapy Using SONALA-001 and Exablate 4000 ...

Diffuse intrinsic pontine glioma (DIPG) is a lethal pediatric brain tumor with no effective therapy and extremely poor prognosis (average 9 months of survival after diagnosis). Because of the location of DIPG tumors within the brainstem, surgical intervention is a highly invasive and imprecise option, as accidental removal of any ...

Exploring therapeutic options for BRCA-mutant DIPG

There is an urgent need for better therapies to treat patients with the most aggressive type of childhood cancer, Diffuse Intrinsic Pontine Glioma (DIPG). DIPG is an incurable brain cancer with 5-year survival of <1%. We have formed an international collaboration to find genetic causes of DIPG, and have made ...