Grant Search

Cancer Type

Keyword Search  

Categories

Grant Amount
>=

<=





Results: 269

The characterisation of diffuse midline gliomas/diffuse intrinsic pontine gliomas ...

High-grade gliomas are a rare group of tumours that can occur anywhere within the central nervous system (brain and spinal cord). They have a dismal prognosis, usually with a < 2 year survival after diagnosis and therefore represent a significant clinical challenge. Diffuse midline gliomas (DMG) and diffuse intrinsic pontine gliomas (...

Targeting Histone Lysine Demethylases to Treat Diffuse Intrinsic Pontine Glioma

Diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPG), are devastating childhood brain tumors that occur in the central portions of the brain. Traditional chemotherapies do not work on them, and because of their location they cannot be removed by surgery. Radiation therapy slows tumor growth, but progression is ...

Glycan Signatures of Resistance in Diffuse Intrinsic Pontine Glioma (DIPG)

Diffuse intrinsic pontine glioma (DIPG) is a brain tumor that primarily affects young children ages 5-9 and claims nearly all its victims in less than 2 years. DIPG tumors are located in the brainstem, rendering them inoperable, and radiation, the only FDA-approved treatment, inevitably results in recurrence as tumor cells develop ...

Viroimmunotherapy for pediatric brain tumors

ABSTRACT Despite decades of efforts, the median survival for patients with diffuse intrinsic pontine glioma (DIPG) is less than 1 year from diagnosis, and the 5-year survival is virtually 0%. Effective treatments for these tumors are an unmet need. Recently, in a phase I trial for naïve DIPGs, Delta-24...

Combining innovative proton radiotherapy with targeted and immune therapies to ...

Diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPG), are devastating childhood brain tumors that occur in the central portions of the brain. Traditional chemotherapies don’t work on them, and because of their location they cannot be removed by surgery. Radiation therapy slows tumor growth, but progression ...

Targeting Aquaporin 1 to treat edema in brain tumor

Brain edema is a major cause of death for brain cancer. Edema surrounding the tumor results from disruption of the blood-brain barrier (BBB), allowing leakage of excess fluid across the blood vessel wall, which leads to swelling brain tissues and a rapid increase in pressure within the skull. Although the ...