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Results: 178

Targeting DIPGs through Super-activation of Steroid Receptor Co-activators: An in ...

The objective of this application is to determine if combining ionizing radiation with the newly-described steroid receptor co-activator (SRC) small molecule stimulator MCB-613 will lead to enhanced tumor cell killing and significantlyimproved therapeutic efficacyin vivo in patient tumor-derived orthotopic xenograft (PDOX) mouse models of diffuse intrinsic pontine glioma (DIPG). DIPG ...

Increased Tenascin-C (TNC) protein expression in tumor tissue and CSF ...

Innovation: Diffuse intrinsic pontine glioma (DIPG) is the most deadly solid tumor in children, with rapid progression, poor response to therapy, and average survival less than one year from diagnosis.  We describe a hypothesis-driven research plan to elucidate the mechanism by which Tenascin-C (TNC), an extracellular matrix (ECM) protein ...

Validation of TAK228 as an effective drug for treating children ...

Validation of TAK228 as an Effective Drug for Treating Children Diagnosed with DIPG Diffuse intrinsic pontine glioma (DIPG) is an untreatable childhood cancer.  DIPGs develop in pons making them surgically unresectable.  We and others have identified mutations in histone and their obligate partner mutations that seem to drive ...

Establishment of an International Diffuse Intrinsic Pontine Glioma (DIPG) Registry

Brainstem gliomas account for up to 20% of all CNS tumors in children with a median age at presentation of 6-7 years.1  Diffuse intrinsic pontine gliomas (DIPG) comprise 80% of all brainstem gliomas. In North America and Europe, approximately 300 children develop brainstem gliomas per year. 2 Prognosis for patients with DIPGs remains ...

Development of a new and effective therapy against Diffuse Intrinsic ...

Diffuse intrinsic pontine glioma (DIPG) is a rare paediatric brain cancer that is almost universally fatal. Surgery is generally too risky and standard chemotherapy is ineffective. Radiation is the only treatment currently available with proven, yet temporary, benefits. There is no cure for DIPG. Targeted therapy uses ...