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Results: 269

INNOVATIVE MODELS OF THE BRAIN MICROENVIRONMENT TO IDENTIFY NEW TREATMENTS ...

Brain tumors are the leading cause of disease related mortality in children. Survival rates for children diagnosed with medulloblastoma (MB), the most common malignant pediatric brain tumor, have stagnated for decades. Despite aggressive treatment approaches, a significant proportion of patients&...

DMG COMBATT 2.0: Diffuse Midline Glioma COMbined Anti-Tumor Targeting 2.0

This proposal is a continuation of our project ‘COMBATT DMG’ supported by the DMG Collaborative in 2020. In COMBATT DMG we developed a catalog of new, central nervous system (CNS)-active drugs targeting ‘Protein kinase C’ (PKC). PKC is a signaling gene that drives the disseminative growth ...

TRANSLATING MECHANISM TO PATIENT BENEFIT FOR ACVR1-MUTANT DIFFUSE INTRINSIC ...

Diffuse intrinsic pontine glioma, or DIPG, is a childhood brain tumor occuring in the brainstem of young children, for which there is currently no cure. Until recently, little was known about the makeup of this type of cancer, and treatments used for other adult brain tumor types consistently failed. Through ...

Discovering new epigenetic players of DIPG (Application for an extension)

Diffuse intrinsic pontine glioma (DIPG) is the most aggressive brain tumour in children. Every year, about 150-300 children in the USA and 3,000 children worldwide are diagnosed with DIPG. The prognosis of DIPG is devastating as only 10% of the patients will live for more than two years1,2. In the ...

Harnessing brain resident immune cells to attack high risk medulloblastoma ...

ABSTRACT We focus on family desires to find therapies that improve cure rates, whilst minimizing long-term side effects for deadly brain cancers. Given radiotherapy (RT) is a common brain cancer treatment, our collaborative team focusses on drugs that enhance RT for high-risk medulloblastoma patients. A major caveat in past childhood ...

THE ROLE OF QPRT AND NAD PATHWAYS IN DIPG TREATMENT ...

The proposed studies build upon preliminary findings from Year 1 of our funding to provide new insights into the role of mediators of NAD+ biosynthesis and energy metabolism in the treatment-resistance of pediatric diffuse midline gliomas (DMGs), including diffuse intrinsic pontine gliomas (DIPGs) and other childhood high-grade gliomas (HGG), the most ...