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Results: 178

study of radiotherapy and concurrent bevacizumab temozolamide followed by bevacizumab. ...

Five-year overall survival in children with high-grade glioma (HGG) and diffuse, intrinsic brainstem glioma (DIPG) are  approximately 25% and 10%, respectively 1-3.  Achieving cure for all children with HGG and DIPG  remains a major goal of pediatric neuro-oncology. DIPGs are infiltrative gliomas, and have typically been found to be &...

Developing new epigenetic combination treatments against DIPG

Diffuse intrinsic pontine glioma (DIPG) is the most aggressive of all childhood cancers. Standard treatment with radiotherapy is only palliative and single drug chemotherapy is ineffective. We have found that DIPG cells are sensitive to a novel anticancer treatment. CBL0137 is a novel class of anticancer agents that can inhibit ...

Synthetic lethality screening with methionine restriction for treatment of DIPG

DIPG is incurable cancer that is the number one cause of cancer-related deaths in children. DIPG is hard to treat because of the surgically inaccessible location, blood-brain barrier which limits some therapies and toxicity considerations related to the young age of DIPG patients. We have focused our efforts on finding ...

Targeting post-translational protein modification to halt Diffuse Intrinsic Pontine Glioma ...

Diffuse intrinsic pontine gliomas (DIPG) are a devastating childhood brain cancer which are universally fatal. Currently DIPG remain incurable as no therapy has been developed that can target underlying processes involved in the pathogenesis of this disease. While key driver mutation have been identified (such as histone mutations), ...

Single-cell profiling and targeting of developmentally regulated signaling programs in ...

Background:  As in other malignant gliomas, there is evidence that DIPG is organized as an aberrant developmental hierarchy originating from rare, treatment-resistant tumor-initiating cells (TICs), also referred to as “cancer stem cells”. Although TICs are potentially important drug targets, they are a challenge to study directly because ...