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Results: 178

CSF Cell-free Tumor DNA (CSF cfDNA) Liquid Biopsies for Pediatric, ...

Pediatric brain tumors are the leading cause of cancer-related death in children and adolescents [1]. Recent advances in molecular analysis have led to major improvements in diagnostic accuracy and prognostication for pediatric patients with brain tumors, allowing physicians to adapt available therapies to specific patient’s needs[2-4]. However, access ...

Rapid Preclinical Development of a Targeted Therapy Combination for DIPG

    Patients with diffuse intrinsic pontine gliomas (DIPGs) have a uniformly dismal prognosis with a median survival of 9 months and long-term survival of less than 1%.  Radiotherapy provides only temporary improvement of symptoms.  No chemotherapy has ever proven effective. Novel therapies are desperately needed in this vulnerable population. ...

Defining the cellular archetecture of diffuse intrinsic pontine glioma through ...

Single-cell genomic profiling is revolutionizing our understanding of tumor biology, as it enables for the first time a genome-wide interrogation of tumor programs at cellular resolution, offering unprecedented insights into tumor cells and their micro-environment at a depth that was unthinkable even a few years ago. I expect that defining ...

POLYAMINE PATHWAY METABOLISM AS A NOVEL THERAPEUTIC OPTION FOR DIFFUSE ...

Diffuse intrinsic pontine glioma (DIPG) is the most aggressive of all childhood cancers. Standard treatment with radiotherapy is only palliative and chemotherapy has been found ineffective. Polyamines are organic compounds essential for key functions of living cells. They can be made by human cells but also generated from intestinal microorganisms ...

Investigating the role of DIPG-derived exosomes in tumor growth and ...

Diffuse Intrinsic Pontine Glioma (DIPG) is a highly aggressive and infiltrating brain tumor affecting children for which there is no effective treatment. Sequencing data have revealed  the existence of well defined subgroups of tumors based on age of onset, specific location in the brain, mutations and clinical outcome. Those ...