Grant Search

Cancer Type

Keyword Search  

Categories

Grant Amount
>=

<=





Results: 178

PHASE I STUDY OF THE COMBINATION OF VANDETANIB AND DASATINIB ...

Diffuse intrinsic pontine glioma (DIPG) is the most lethal brain tumor in children. Despite treatment with radiation therapy (RT) with or without chemotherapy, the long-term survival of affected children has remained < 10%. Radical surgery is not feasible for children with DIPG. Although RT is the mainstay of therapy, the response ...

Enabling epigenetic therapies by exploring DIPG chromatin sensitivities

Background: Recently, driver mutations in histone H3 have been found to correlate with particularly malignant forms of DIPG. These mutations change lysine 27 of H3 to methionine (K27M), abrogating methylation and acetylation at this site, both of which are epigenetic marks that influence chromatin architecture and are important for regulating ...

THE EVOLUTIONARY DYNAMICS OF DIFFUSE INTRINSIC PONTINE GLIOMA

Diffuse intrinsic pontine glioma are high grade glial tumours arising in the brainstem with a median survival of 9-12 months, and a distinct biology compared to similar looking tumours arising in the cerebral hemispheres in children and adults. A major challenge to improve outcomes for these tumours is their extensive ...

Expansion of the International Diffuse Intrinsic Pontine Glioma (DIPG) Registry

Diffuse intrinsic pontine gliomas (DIPG) are the most common brainstem tumors in children, representing approximately 75-80% of all pediatric brainstem tumors. 1 Approximately 200-300 patients are diagnosed with DIPG in all of North America and Europe.  1,2 DIPG  accounts for 10-15% of all new pediatric brain tumor diagnoses and is ...

Cellular Cybercriminals: DIPG Hacks into the Neural Communication Infrastructure

 My group has recently demonstrated the neuronal activity drives the growth of DIPG and other high-grade gliomas. One way that active neurons promote DIPG growth is through activity-regulated secretion of growth factors into the tumor microenvironment. We have now discovered an additional, surprising means of neuron:glioma communication – ...