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Results: 269

Development of a new and effective therapy against Diffuse Intrinsic ...

Diffuse intrinsic pontine glioma (DIPG) is a rare paediatric brain cancer that is almost universally fatal. Surgery is generally too risky and standard chemotherapy is ineffective. Radiation is the only treatment currently available with proven, yet temporary, benefits. There is no cure for DIPG. Targeted therapy uses ...

Using Imaging Mass Cytometry to identify Next Generation Imaging Biomarkers ...

The field of pediatric neuro-oncology has been greatly advanced by recent studies, which have better outlined the spectrum of pediatric Central Nervous System (CNS) tumors, into more clearly distinct biological and clinico-pathological tumor entities. Unfortunately, what is still missing, is the consideration of the tumor as a whole, with and ...

Development of Novel Histone Demethylase Inhibitor against DIPG

For a child is diagnosed with a diffuse intrinsic pontine glioma so called DIPG, the options for treatment are scarce and so are the chances for survival. This aggressive brain tumor generally strikes children who are 6 years old and younger, with most surviving less than two year after diagnosis. DIPG ...

Methionine deprivation as a therapeutic strategy for diffuse intrinsic pontine ...

After decades of clinical trials, no effective treatment has yet been found for DIPG. While we now know a lot about the genetics of this disease, this has unfortunately not thus far led to improved survival for children with DIPG. To better understand ...

Responses of distinct cell populations to PDGFRA inhibitors in diffuse ...

No cure has been found for diffuse intrinsic pontine glioma (DIPG), after more than 250 clinical trials.  Evidence for excessive signaling by platelet-derived growth factor receptor alpha (PDGFRA) is commonly found in biopsies of DIPG, but attempts to inhibit this protein has failed as a clinical strategy. &...

TARGETING TOP3A-AMPLIFIED DIPG CELLS BY SIRTUIN INHIBITION

Diffuse intrinsic pontine glioma (DIPG) is a malignant brainstem tumour arising in children representing a major unmet clinical need, with a 2-year survival rate close to zero. With chemotherapy ineffective and surgical intervention not possible, new therapeutic approaches are urgently required based upon the unique biological mechanisms driving DIPG tumorigenesis. ...