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Results: 178

Targeting diffuse midline gliomas with innovative T cell immunotherapy

Diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPG), are highly aggressive brain tumors that mainly affect children and currently have no cure. Traditional treatments like chemotherapy and radiation have limited success, leaving an urgent need for new therapies to improve survival rates while minimizing side effects. Chimeric antigen ...

targeted therapy and stem cell therapy for DIPG

BACKGROUND: Diffuse intrinsic pontine glioma (DIPG) is the leading cause of brain cancer associated deaths in children despite constituting only 10-15% of childhood brain tumours.  Approximately 300 children per year with a median age of 6-7 years will be diagnosed with DIPG in the US [about 20 per year in Australia]. &...

Mitochondrial DNA alterations and their potential as a novel therapeutic ...

Brain tumors are the leading cause of cancer-related death in childhood. Diffuse intrinsic pontine glioma (DIPG) arises in the pons of the brainstem and is universally fatal, comprising nearly 15% of all pediatric brain tumors.1 Despite international endeavors to improve outcome, DIPGs show poor response to conventional radiation and chemotherapeutic strategies ...

Targeting EZH2 as a theraputic strategy in DIPG

Malignant brain tumors are the leading cause of cancer-related mortality in children (1), and diffuse intrinsic pontine glioma (DIPG) is one of the most devastating, with a median survival of <1 year following treatment with radiation therapy (2). Despite more than 250 clinical trials over the past 30 years (3), not a single chemotherapeutic agent ...

TARGETING TOP3A-AMPLIFIED DIPG CELLS BY SIRTUIN INHIBITION

Diffuse intrinsic pontine glioma (DIPG) is a malignant brainstem tumour arising in children representing a major unmet clinical need, with a 2-year survival rate close to zero. With chemotherapy ineffective and surgical intervention not possible, new therapeutic approaches are urgently required based upon the unique biological mechanisms driving DIPG tumorigenesis. ...