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Results: 269

Investigation Toward a Multimodality, Combination Treatment Strategy for DIPG/DMG

DIPG is an aggressive childhood brain tumor that is nearly always fatal. Although most past patients have died of the tumor pushing on the brainstem’s pons area, DIPG spreads to other parts of the brain and spinal cord, known as the central nervous system (CNS). To cure DIPG, ...

Co-culture disruptor screens to target cell-cell interactions in DMG

Diffuse midline glioma (DMG) is a malignant brain tumour arising in children representing a major unmet clinical need, with a 2-year survival rate close to zero. Existing treatments based upon targeting the genetic faults within the tumour cells have not yet produced any meaningful survival benefit, and so innovative solutions ...

Nuclear receptor NR5A2 as a therapeutic target for pediatric ...

Brain tumors are the predominant cause of cancer-associated deaths in children. For example, pediatric diffuse high-grade gliomas carry an extremely unfavourable prognosis with 70–90% of patients dying within 2 years of their initial diagnosis. Unfortunately, treatment for pediatric brain tumors has not radically changed over the past three decades. These ...

COMBATT DMG: Combined anti-tumor targeting of diffuse midline gliomas

Paediatric high-grade glioma of the brainstem – diffuse midline glioma (DMG), represent the most aggressive primary tumor of the central nervous system (CNS) and are responsible for half of all brain cancer deaths in children. Recent scientific advances provide much needed insight into the biology of the disease – particularly ...

Discovering new epigenetic players in DIPG oncogenesis

Diffuse intrinsic pontine glioma (DIPG) is the most aggressive brain tumour in children. DIPG accounts for 10-15 percent of all paediatric central nervous system tumours.  Every year in US 300 children are diagnosed with DIPG and 300 children will die of this disease. By conducting fundamental research, ...

Developing new epigenetic combination treatments against DIPG

Diffuse intrinsic pontine glioma (DIPG) is the most aggressive of all childhood cancers. Standard treatment with radiotherapy is only palliative and single drug chemotherapy is ineffective. We have found that DIPG cells are sensitive to a novel anticancer treatment. CBL0137 is a novel class of anticancer agents that can inhibit ...