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Results: 178

Targeting macrophages to improve the survival of DIPG

Diffuse Intrinsic Pontine Glioma (DIPG) is a type of high-grade pediatric glioma (pHGG) that remains uniformly fatal in 2020, represents the leading cause of death for pediatric brain tumor patients, and for which the standard of care has not improved in over 50 years. Improvements in outcomes require the identification of ...

PHASE I STUDY OF THE COMBINATION OF VANDETANIB AND DASATINIB ...

Diffuse intrinsic pontine glioma (DIPG) is the most lethal brain tumor in children. Despite treatment with radiation therapy (RT) with or without chemotherapy, the long-term survival of affected children has remained < 10%. Radical surgery is not feasible for children with DIPG. Although RT is the mainstay of therapy, the response ...

Enabling epigenetic therapies by exploring DIPG chromatin sensitivities

Background: Recently, driver mutations in histone H3 have been found to correlate with particularly malignant forms of DIPG. These mutations change lysine 27 of H3 to methionine (K27M), abrogating methylation and acetylation at this site, both of which are epigenetic marks that influence chromatin architecture and are important for regulating ...

THE EVOLUTIONARY DYNAMICS OF DIFFUSE INTRINSIC PONTINE GLIOMA

Diffuse intrinsic pontine glioma are high grade glial tumours arising in the brainstem with a median survival of 9-12 months, and a distinct biology compared to similar looking tumours arising in the cerebral hemispheres in children and adults. A major challenge to improve outcomes for these tumours is their extensive ...

Expansion of the International Diffuse Intrinsic Pontine Glioma (DIPG) Registry

Diffuse intrinsic pontine gliomas (DIPG) are the most common brainstem tumors in children, representing approximately 75-80% of all pediatric brainstem tumors. 1 Approximately 200-300 patients are diagnosed with DIPG in all of North America and Europe.  1,2 DIPG  accounts for 10-15% of all new pediatric brain tumor diagnoses and is ...