Grant Search

Cancer Type

Keyword Search  

Categories

Grant Amount
>=

<=





Results: 178

Methionine deprivation as a therapeutic strategy for diffuse intrinsic pontine ...

After decades of clinical trials, no effective treatment has yet been found for DIPG. While we now know a lot about the genetics of this disease, this has unfortunately not thus far led to improved survival for children with DIPG. To better understand ...

DMG COMBATT 2.0: Diffuse Midline Glioma COMbined Anti-Tumor Targeting 2.0

This proposal is a continuation of our project ‘COMBATT DMG’ supported by the DMG Collaborative in 2020. In COMBATT DMG we developed a catalog of new, central nervous system (CNS)-active drugs targeting ‘Protein kinase C’ (PKC). PKC is a signaling gene that drives the disseminative growth ...

A Phase 1/2 Study of Sonodynamic Therapy Using SONALA-001 and Exablate 4000 ...

Diffuse intrinsic pontine glioma (DIPG) is a lethal pediatric brain tumor with no effective therapy and extremely poor prognosis (average 9 months of survival after diagnosis). Because of the location of DIPG tumors within the brainstem, surgical intervention is a highly invasive and imprecise option, as accidental removal of any ...

Phase II trial of molecularly determined treatment of children and ...

Scientific Merit: The prognosis of diffuse intrinsic pontine gliomas (DIPGs) has not improved significantly over the last 40 years.  A major reason for this limitation is the lack of an understanding of the underlying biology of these tumors, as well as the absence of appropriate targets for therapeutic intervention.  ...

Exploring the interactome of H3K27M to find theraputic ...

We now have a wealth of genetic and epigenetic information about DIPG. However, relatively little is known about the molecular consequences downstream from H3K27M mutations and how they can lead to cancer formation. It is known that, as well as DNA hypomethylation, H3K27M mutation leads to ...