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Results: 269

Repurposing antimalarial drugs for DIPG therapy

Diffuse intrinsic pontine gliomas (DIPGs) are rare but highly aggressive brain tumors found in the pons, an area of the brainstem that controls many of the body’s most vital functions such as breathing, blood pressure, and heart rate. Despite DIPG being the leading cause of pediatric death by ...

Eliminating Therapy-Resistant Diffuse Intrinsic Pontine Gliomas with Oncolytic Picorna Virus ...

Diffuse intrinsic pontine glioma (DIPG) is the most lethal childhood cancer, and virtually all children with this disease die within 1-2 years of diagnosis. Major challenges for the development of new therapies include the lack of clinically relevant animal model system,difficulties of efficient drug delivery across the blood brain ...

TELOMERASE: A THERAPEUTIC TARGET IN PEDIATRIC BRAIN TUMORS

Five-year overall survival in childhood high-grade gliomas (HGG) and disseminated high-risk medulloblastoma is 25% and 30%. Moreover, hemispheric or craniospinal radiotherapy, at a young age leads to devastating neurocognitive decline. Achieving a cure for children with these poor prognosis malignancies while minimizing radiotherapy-associated sequelae remains a major goal of pediatric neuro-oncology.  ...

study of radiotherapy and concurrent bevacizumab temozolamide followed by bevacizumab. ...

Five-year overall survival in children with high-grade glioma (HGG) and diffuse, intrinsic brainstem glioma (DIPG) are  approximately 25% and 10%, respectively 1-3.  Achieving cure for all children with HGG and DIPG  remains a major goal of pediatric neuro-oncology. DIPGs are infiltrative gliomas, and have typically been found to be &...

Establishment of an International Diffuse Intrinsic Pontine Glioma (DIPG) Registry

Brainstem gliomas account for up to 20% of all CNS tumors in children with a median age at presentation of 6-7 years.1  Diffuse intrinsic pontine gliomas (DIPG) comprise 80% of all brainstem gliomas. In North America and Europe, approximately 300 children develop brainstem gliomas per year. 2 Prognosis for patients with DIPGs remains ...

Targeting DIPGs in vivo in Intra-brain Stem Xenograft Mouse Models ...

The objective of this application is to examine if combining ionizing radiation with an oncolytic virus SVV-001 would lead to synergistically enhanced tumor cell killing and significantly improve therapeutic efficacy in vivo in patient tumor-derived intra-brainstem xenograft mouse models of diffuse intrinsic pontine glioma (DIPG). DIPG is the most lethal ...