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Results: 178

Development of a new and effective therapy against Diffuse Intrinsic ...

Diffuse intrinsic pontine glioma (DIPG) is a rare paediatric brain cancer that is almost universally fatal. Surgery is generally too risky and standard chemotherapy is ineffective. Radiation is the only treatment currently available with proven, yet temporary, benefits. There is no cure for DIPG. Targeted therapy uses ...

EPIGENETIC ALTERATIONS AS THERAPEUTIC TARGETS IN PEDIATRIC BRAIN TUMORS

We and others co-discovered the presence of activating mutations in ACVR1 in 25% of human DIPGs in 2014. Subsequently, my laboratory has developed a murine DIPG model incorporating R206H ACVR1 and observed that R206H ACVR1 significantly accelerates brainstem gliomagenesis. In addition, short-term treatment with a bone morphogenetic protein pathway inhibitor (...

Preclinical evaluation of TP-0184 in an autochthonous mouse model of ...

Evaluation of new cancer drugs, and determining which models best predict whether the new cancer drug will benefit children with DMG/DIPG is unclear.   DMG/DIPG tumor cells have complex interactions with cell types normally found in the brain. Therefore, new therapies must be evaluated in animal models ...

Establishment and characterization of renewable tissue resources for dipg research

Background:  Due to their vital location, diffuse intrinsic pontine gliomas (DIPGs) are not treated surgically, and the lack of tumor material for research has greatly limited research efforts [1]. Recently, our group and others have used autopsy tissue, and rare biopsy tissues, for genetic analyses of DIPG to identify the ...

Investigating the role of DIPG-derived exosomes in tumor growth and ...

Diffuse intrinsic pontine glioma (DIPG) is a devastating brain tumor which affects children and for which there is no effective treatment at the moment.  We and others have recently shown that DIPG is characterized by a remarkable degree of intratumoral heterogeneity and consists of distinct genetically and phenotypically heterogeneous ...