Grant Search

Cancer Type

Keyword Search  

Categories

Grant Amount
>=

<=





Results: 192

EphB3 controls DIPG invasion via regulation of glioma-to-neuron synaptogenesis

Diffuse Intrinsic Pontine Glioma (DIPG), is a highly aggressive, universally fatal brain stem glioma arising in young children.1 There are no effective therapies for DIPG and children typically succumb to the disease within two years of diagnosis.2 Previous studies have shown that DIPG tumours actively communicate with neurons, a phenomenon ...

Identify molecular features of Richter syndrome by single-cell transcriptome and 3...

Abstract: Our research project aims to explore the mysterious changes that occur in a type of blood cancer called Richter Syndrome (RS). RS is what happens when a slow-growing leukemia, known as chronic lymphocytic leukemia (CLL), suddenly transforms into a much more aggressive form of lymphoma. This transformation is difficult ...

Discovery of new therapies for Diffuse intrinsic pontine glioma (DIPG) ...

Diffuse intrinsic pontine glioma (DIPG) is the most lethal brain tumor in children, with a survival time of only 9-11 months. Despite many years of research, there is still no cure for DIPG, highlighting the urgent need for new treatments. Circular RNAs (circRNAs) are a new type of RNA that ...

Inducing iron overload by targeting iron-sulfur transport can activate ferroptosis ...

Abstract Medulloblastomas (MB) are amongst the most common and deadliest brain tumors of childhood. They are divided into four groups; group 3 (G3MB) patients have the lowest survival. Presently, all patients receive the same therapies, starting with surgical resection, followed by radiation and chemotherapy. G3MBs do not respond well ...

An AI-driven integrated risk score for improving survival outcomes in ...

This project focuses on developing a non-invasive AI-driven integrated risk score for improving survival outcomes in pediatric Medulloblastoma (MB). MB is the most frequent malignant brain tumor in children, accounting for 20% of pediatric intracranial tumors, and the 5-year survival rate is 60-80%.  Relapse in MB is nearly fatal, making ...