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Results: 86

Targeting DIPG through combining a super-activator (MCB-613) of steroid receptor ...

The objective of this application is to demonstrate that combining MCB-613, a small molecule stimulator of the oncogenic steroid receptor co-activator (SRC), with ionizing radiation would synergistically kill tumor cells of diffuse intrinsic pontine glioma (DIPG) in vivo and significantly prolong survival times in patient tumor-derived orthotopic (intra-brain stem) xenograft (...

Methionine deprivation as a therapeutic strategy for diffuse intrinsic pontine ...

After decades of clinical trials, no effective treatment has yet been found for DIPG. While we now know a lot about the genetics of this disease, this has unfortunately not thus far led to improved survival for children with DIPG. To better understand ...

Defining the molecular mechanisms of DIPG development and progression to ...

  Diffuse Intrinsic Pontine Gliomas (DIPGs) are devastating pediatric brainstem tumors that lack effective treatment and are uniformly fatal. Patient studies have identified recurrent genetic lesions that drive the development of these tumors. Almost all DIPGs carry mutations in genes encoding either replication-dependent histone-H3 proteins (mostly HIST1H3B) or ...

An open label single arm phase I/II study of ...

We propose a phase I/limited efficacy clinical trial investigating repeated administration of MTX110, a soluble form of panobinostat, given via convection-enhanced delivery (CED) to pediatric patients with newly diagnosed diffuse intrinsic pontine glioma (DIPG). We hypothesize this therapy will be safe and well-tolerated and will be efficacious and prolong ...

Responses of distinct cell populations to PDGFRA inhibitors in diffuse ...

No cure has been found for diffuse intrinsic pontine glioma (DIPG), after more than 250 clinical trials.  Evidence for excessive signaling by platelet-derived growth factor receptor alpha (PDGFRA) is commonly found in biopsies of DIPG, but attempts to inhibit this protein has failed as a clinical strategy. &...