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Results: 192

TRANSLATING MECHANISM TO PATIENT BENEFIT FOR ACVR1-MUTANT DIFFUSE INTRINSIC ...

Diffuse intrinsic pontine glioma, or DIPG, is a childhood brain tumor occuring in the brainstem of young children, for which there is currently no cure. Until recently, little was known about the makeup of this type of cancer, and treatments used for other adult brain tumor types consistently failed. Through ...

CD200 Activation Receptor Ligand (CD200AR-L) and Allogeneic Tumor Lysate ...

This is a multi-center Phase I study of a new adjuvant CD200 activation receptor ligand (CD200AR-L) in combination with imiquimod and the GBM6- AD brain tumor vaccine to treat newly diagnosed diffuse midline glioma malignant glioma and recurrent high grade glioma in Children. The Olin lab ...

The therapeutic ketogenic diet for the adjuvant treatment of DIPG

Diffuse Intrinsic Pontine Glioma (DIPG) is a highly infiltrative pediatric tumor with a median survival of ~9 months. Radiation is the standard of care; however, this provides only short term benefits and to date, other therapy trials have shown relatively little success and/or unacceptable side effects. This has led parents ...

Clinical development of the novel immunotoxin, GB13, for the treatment ...

Diffuse Intrinsic Pontine Glioma (DIPG) is a rare, pediatric tumor typically arising in the brainstem with no effective treatment options. Every year approximately 400 children in the US are diagnosed with this disease. Physical location, the blood-brain barrier and limited characterization of DIPG have played key roles in the inability ...

Controlling DIPG/DMG with the protein kinase C-iota inhibitor ICA-1...

Pediatric Diffuse Intrinsic Pontine Glioma (DIPG) and Diffuse Midline Glioma (DMG) are currently incurable childhood brain tumors. Elucidating the regulation of signaling pathways in pediatric DIPG and DMG is critical to targeting tumor cell migration and spreading.  Until these pathways are understood, comprehensive and effective treatment of this group ...