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Results: 152

Exploring the interactome of H3K27M to find theraputic ...

We now have a wealth of genetic and epigenetic information about DIPG. However, relatively little is known about the molecular consequences downstream from H3K27M mutations and how they can lead to cancer formation. It is known that, as well as DNA hypomethylation, H3K27M mutation leads to ...

Targeting DIPG through pharmacological activation of mitochondrial biogenesis: as in ...

Diffuse intrinsic pontine gliomas (DIPG) are infiltrative, highly aggressive pediatric brainstem tumors with limited therapeutic options. Despite international efforts to improve outcome, DIPG show poor response to conventional radiation and chemotherapeutic strategies. Only within the last decade have studies really begun to decipher the molecular mechanisms behind DIPG tumorigenesis, with ...

Sequential phase I studies of nivolumab monotherapy and nivolumab in ...

Developing effective treatments for pediatric CNS tumors arguably represents the major remaining unmet need in pediatric oncology.  We propose a phase I study of nivolumab and then another phase I study of the combination of ipilimumab and nivolumab in children with recurrent/refractory brain tumors. Ipilimumab ...

TARGETING TOP3A-AMPLIFIED DIPG CELLS BY SIRTUIN INHIBITION

Diffuse intrinsic pontine glioma (DIPG) is a malignant brainstem tumour arising in children representing a major unmet clinical need, with a 2-year survival rate close to zero. With chemotherapy ineffective and surgical intervention not possible, new therapeutic approaches are urgently required based upon the unique biological mechanisms driving DIPG tumorigenesis. ...

targeted therapy and stem cell therapy for DIPG

BACKGROUND: Diffuse intrinsic pontine glioma (DIPG) is the leading cause of brain cancer associated deaths in children despite constituting only 10-15% of childhood brain tumours.  Approximately 300 children per year with a median age of 6-7 years will be diagnosed with DIPG in the US [about 20 per year in Australia]. &...