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Results: 185

The characterisation of diffuse midline gliomas/diffuse intrinsic pontine gliomas ...

High-grade gliomas are a rare group of tumours that can occur anywhere within the central nervous system (brain and spinal cord). They have a dismal prognosis, usually with a < 2 year survival after diagnosis and therefore represent a significant clinical challenge. Diffuse midline gliomas (DMG) and diffuse intrinsic pontine gliomas (...

Glycan Signatures of Resistance in Diffuse Intrinsic Pontine Glioma (DIPG)

Diffuse intrinsic pontine glioma (DIPG) is a brain tumor that primarily affects young children ages 5-9 and claims nearly all its victims in less than 2 years. DIPG tumors are located in the brainstem, rendering them inoperable, and radiation, the only FDA-approved treatment, inevitably results in recurrence as tumor cells develop ...

Targeting Aquaporin 1 to treat edema in brain tumor

Brain edema is a major cause of death for brain cancer. Edema surrounding the tumor results from disruption of the blood-brain barrier (BBB), allowing leakage of excess fluid across the blood vessel wall, which leads to swelling brain tissues and a rapid increase in pressure within the skull. Although the ...

Epigenetic Regulation of Cell Fate Reprogramming in H3K27M-altered ...

Diffuse midline glioma, including those located at the pons in the brainstem (diffuse intrinsic pontine gliomas, DIPGs) are childhood brain tumors and patients with DIPG have a poor prognosis with a median survival time less than 1 year from diagnosis. Currently, apart from radiation therapy, which partially slows down tumor growth, ...

Phase 2 Study of Systemic IL-6 Receptor Antagonist ACTEMRA® (tocilizumab) for ...

This proposal is designed to help support a novel international clinical trial for children with the highly morbid brain tumor, Adamantinomatous Craniopharyngioma (ACP).  ACP is a solid/cystic tumor that originates in the sellar/suprasellar region at the base of the brain, adjacent to critical structures for vision, hormone ...