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Results: 139

Using zebrafish to accelerate DIPG drug development

A critical barrier to improvements in diffuse intrinsic pontine glioma (DIPG) therapy is a lack of new drugs that have a broad therapeutic index. In DIPG, validation of new therapeutics is hampered by the long time (6 months) that most human DIPG tumors take to kill mice. This means that it ...

COMBATT DMG: Combined anti-tumor targeting of diffuse midline gliomas

Paediatric high-grade glioma of the brainstem – diffuse midline glioma (DMG), represent the most aggressive primary tumor of the central nervous system (CNS) and are responsible for half of all brain cancer deaths in children. Recent scientific advances provide much needed insight into the biology of the disease – particularly ...

Discovering novel epigenetic dependencies in Diffuse Intrinsic Pontine Glioma

 Scientific Merit  Recent genetic analyses have revealed specific and unique K27M mutations in the histone 3.3 side chain in more than 90% of DIPG cases.  Post-translational modifications of this histone 3.3 side chain are normally used as a “histone code” for fine-tuning gene expression across the whole ...

Establishment of a pre-clinical model for pediatric glioblastoma

Glioblastoma is a highly aggressive astrocytoma affecting thousands of adults and children each year in the United States. Current treatments are ineffective and as a consequence, overall survival is dismal. Moreover, there have been few clinical gains achieved in the last three decades. Accumulating evidence obtained through the study of ...

Intra-tumoral heterogeneity in diffuse intrinsic pontine and midline high-grade gliomas

Background: Diffuse intrinsic pontine glioma (DIPG) is a lethal pediatric brain tumor that affects approximately 150 children in North America each year.1 Though radiation therapy can prolong survival by 2-3 months, adjuvant chemotherapy has not improved outcome. The median survival is less than 12 months and has remained unchanged for the last 30 ...