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Results: 138

Eliminating Therapy-Resistant Diffuse Intrinsic Pontine Gliomas with Oncolytic Picorna Virus ...

Diffuse intrinsic pontine glioma (DIPG) is the most lethal childhood cancer, and virtually all children with this disease die within 1-2 years of diagnosis. Major challenges for the development of new therapies include the lack of clinically relevant animal model system,difficulties of efficient drug delivery across the blood brain ...

Discovering new epigenetic players in DIPG oncogenesis

Diffuse intrinsic pontine glioma (DIPG) is the most aggressive brain tumour in children. DIPG accounts for 10-15 percent of all paediatric central nervous system tumours.  Every year in US 300 children are diagnosed with DIPG and 300 children will die of this disease. By conducting fundamental research, ...

Determine the efficacy of BMP and MEK inhibitors with RT ...

We and others co-discovered the presence of activating mutations in ACVR1 in 25% of human DIPGs in 2014. Subsequently, my laboratory has developed a murine DIPG model incorporating R206H ACVR1 and observed that R206H ACVR1 significantly accelerates brainstem gliomagenesis. In addition, short-term treatment with a bone morphogenetic protein pathway inhibitor (...

Rapid Preclinical Development of a Targeted Therapy Combination for DIPG

    Patients with diffuse intrinsic pontine gliomas (DIPGs) have a uniformly dismal prognosis with a median survival of 9 months and long-term survival of less than 1%.  Radiotherapy provides only temporary improvement of symptoms.  No chemotherapy has ever proven effective. Novel therapies are desperately needed in this vulnerable population. ...

Defining the cellular archetecture of diffuse intrinsic pontine glioma through ...

Single-cell genomic profiling is revolutionizing our understanding of tumor biology, as it enables for the first time a genome-wide interrogation of tumor programs at cellular resolution, offering unprecedented insights into tumor cells and their micro-environment at a depth that was unthinkable even a few years ago. I expect that defining ...