Grant Search

Cancer Type

Keyword Search  

Categories

Grant Amount
>=

<=





Results: 179

Chromatin defects and therapeutic targets in pediatric brain cancers

DNA is wrapped around an octamer of histone proteins, known as a nucleosome, to form the basic repeating unit of chromatin. Genes encoding two chromatin regulators, ATRX and the histone H3.3, are frequently mutated in pediatric glioblastoma (pGBM) which is a lethal form of brain cancer. To translate this new ...

The characterisation of diffuse midline gliomas/diffuse intrinsic pontine gliomas ...

High-grade gliomas are a rare group of tumours that can occur anywhere within the central nervous system (brain and spinal cord). They have a dismal prognosis, usually with a < 2 year survival after diagnosis and therefore represent a significant clinical challenge. Diffuse midline gliomas (DMG) and diffuse intrinsic pontine gliomas (...

SUMOylation as a novel therapeutic target in DIPG

Post-translational protein modification (PTM) is one of the important  mechanisms by which the function of cellular proteins are modulated.  SUMOylation is a  reversible PTM which has emerged as a crucial molecular  mechanism, involved in the control of DNA damage repair, immune responses, carcinogenesis, cell  division ...

Targeting the thioredoxin system as a novel strategy for DIPG

Diffuse intrinsic pontine glioma (DIPG) is the most aggressive of all childhood brain cancers. Radiotherapy treatment is palliative, and chemotherapy is ineffective. We have found that both DIPG cells and DIPG animal models are exquisitely sensitive to auranofin. Auranofin is a gold containing anti-inflammatory compound previously used to treat rheumatoid ...

CXCR1/2 Signaling Pathway: a role in the invasive mechanism of ...

High-grade gliomas (HGGs) make up 8-10% of children's brain tumors and are often fatal within two years. These tumors can develop in the cerebral cortex or infratentorial regions like the brainstem. About half of pediatric HGGs occur in midline locations such as the pons, known as diffuse midline gliomas (...