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Results: 192

Nuclear receptor NR5A2 as a therapeutic target for pediatric ...

Brain tumors are the predominant cause of cancer-associated deaths in children. For example, pediatric diffuse high-grade gliomas carry an extremely unfavourable prognosis with 70–90% of patients dying within 2 years of their initial diagnosis. Unfortunately, treatment for pediatric brain tumors has not radically changed over the past three decades. These ...

Chromatin defects and therapeutic targets in pediatric brain cancers

DNA is wrapped around an octamer of histone proteins, known as a nucleosome, to form the basic repeating unit of chromatin. Genes encoding two chromatin regulators, ATRX and the histone H3.3, are frequently mutated in pediatric glioblastoma (pGBM) which is a lethal form of brain cancer. To translate this new ...

Elucidation of regional differences of ONC201 Response in H3K27...

Diffuse intrinsic pontine glioma (DIPG), recently renamed diffuse midline glioma (DMG), is an extremely aggressive and lethal pediatric brain tumor with no proven therapies beyond standard radiation. As such, few children with this diagnosis survive beyond 2 years, highlighting the dire need to identify and investigate novel genetic therapeutic targets in ...

Discovering new epigenetic players of DIPG (Application for an extension)

Diffuse intrinsic pontine glioma (DIPG) is the most aggressive brain tumour in children. Every year, about 150-300 children in the USA and 3,000 children worldwide are diagnosed with DIPG. The prognosis of DIPG is devastating as only 10% of the patients will live for more than two years1,2. In the ...

Harnessing brain resident immune cells to attack high risk medulloblastoma ...

ABSTRACT We focus on family desires to find therapies that improve cure rates, whilst minimizing long-term side effects for deadly brain cancers. Given radiotherapy (RT) is a common brain cancer treatment, our collaborative team focusses on drugs that enhance RT for high-risk medulloblastoma patients. A major caveat in past childhood ...

Acute Lymphoblastic Leukemia (ALL)
Acute Myeloid Leukemia (AML)
Adrenocortical Carcinoma
AIDS-Related Lymphoma (Lymphoma)
Anal Cancer
Astrocytomas, Childhood (Brain Cancer)
Atypical Teratoid/Rhabdoid Tumor, Childhood (Brain Cancer)
Bile Duct Cancer
Bladder Cancer
Bone Cancer (includes Ewing Sarcoma and Osteosarcoma and Malignant Fibrous Histiocytoma)
Brain Tumors (General)
Breast Cancer
Carcinoid Tumor (Gastrointestinal)
Carcinoma of Unknown Primary
Cervical Cancer
Chronic Lymphocytic Leukemia (CLL)
Chronic Myelogenous Leukemia (CML)
Chronic Myeloproliferative Neoplasms
Colorectal Cancer
Craniopharyngioma, Childhood (Brain Cancer)
DIPG, Childhood (Brain Cancer)
Embryonal Tumors, Childhood (Brain Cancer)
Endometrial Cancer (Uterine Cancer)
Ependymoma, Childhood (Brain Cancer)
Esophageal Cancer
Ewing Sarcoma (Bone Cancer)
Extracranial Germ Cell Tumor, Childhood
Extragonadal Germ Cell Tumor
Eye Cancer
Fallopian Tube Cancer
Fibrous Histiocytoma of Bone, Malignant, and Osteosarcoma
Gallbladder Cancer
Gastric (Stomach) Cancer
Gastrointestinal Carcinoid Tumors
Gastrointestinal Stromal Tumors (GIST) (Soft Tissue Sarcoma)
Germ Cell Tumors
Gestational Trophoblastic Disease
Hepatocellular (Liver) Cancer
Histiocytosis, Langerhans Cell
Hodgkin Lymphoma
Hypopharyngeal Cancer
Intraocular Melanoma
Islet Cell Tumors, Pancreatic Neuroendocrine Tumors
Kaposi Sarcoma (Soft Tissue Sarcoma)
Kidney (Renal Cell) Cancer
Langerhans Cell Histiocytosis
Laryngeal Cancer (Head and Neck Cancer)
Leukemia
Lip and Oral Cavity Cancer (Head and Neck Cancer)
Liver Cancer
Lung Cancer (Non-Small Cell and Small Cell)
Lymphoma
Male Breast Cancer
Malignant Fibrous Histiocytoma of Bone and Osteosarcoma
Medulloblastoma, Childhood (Brain Cancer)
Melanoma
Melanoma, Intraocular (Eye)
Merkel Cell Carcinoma (Skin Cancer)
Mesothelioma, Malignant
Metastatic Cancer
Metastatic Squamous Neck Cancer with Occult Primary (Head and Neck Cancer)
Mouth Cancer (Head and Neck Cancer)
Multiple Myeloma/Plasma Cell Neoplasms
Mycosis Fungoides (Lymphoma)
Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Neoplasms
Myelogenous Leukemia, Chronic (CML)
Myeloid Leukemia, Acute (AML)
Myeloproliferative Neoplasms, Chronic
Nasal Cavity and Paranasal Sinus Cancer (Head and Neck Cancer)
Nasopharyngeal Cancer
Neuroblastoma
Non-Hodgkin Lymphoma
Non-Small Cell Lung Cancer
Oral Cancer, Lip and Oral Cavity Cancer and Oropharyngeal Cancer (Head and Neck Cancer)
Oropharyngeal Cancer
Osteosarcoma (Bone Cancer)
Ovarian Cancer
Pancreatic Cancer
Pancreatic Neuroendocrine Tumors (Islet Cell Tumors)
Paraganglioma
Paranasal Sinus and Nasal Cavity Cancer (Head and Neck Cancer)
Parathyroid Cancer
Penile Cancer
Pharyngeal Cancer (Head and Neck Cancer)
Pheochromocytoma
Pituitary Tumor
Plasma Cell Neoplasm/Multiple Myeloma
PNET, Childhood (Brain Cancer)
Pregnancy and Breast Cancer
Primary Central Nervous System (CNS) Lymphoma
Primary CNS Lymphoma
Primary Peritoneal Cancer
Prostate Cancer
Rectal Cancer
Recurrent Cancer
Renal Cell (Kidney) Cancer
Retinoblastoma
Rhabdomyosarcoma, Childhood (Soft Tissue Sarcoma)
Salivary Gland Cancer (Head and Neck Cancer)
Sarcoma
Skin Cancer
Small Cell Lung Cancer
Small Intestine Cancer
Soft Tissue Sarcoma
Squamous Neck Cancer with Occult Primary, Metastatic (Head and Neck Cancer)
Stomach (Gastric) Cancer
Testicular Cancer
Throat Cancer (Head and Neck Cancer)
Thymoma and Thymic Carcinoma
Thyroid Cancer
Transitional Cell Cancer of the Renal Pelvis and Ureter (Kidney (Renal Cell) Cancer)
Ureter and Renal Pelvis, Transitional Cell Cancer (Kidney (Renal Cell) Cancer
Urethral Cancer
Uterine Cancer, Endometrial
Uterine Sarcoma
Vaginal Cancer
Vascular Tumors (Soft Tissue Sarcoma)
Vulvar Cancer
Wilms Tumor and Other Childhood Kidney Tumors