Grant Search

Cancer Type

Keyword Search  

Categories

Grant Amount
>=

<=





Results: 138

Mapping DIPG Tumour Progression and understanding Biological Heterogeneity using Spatial ...

Diffuse Intrinsic Pontine Glioma (DIPG) otherwise known as Diffuse Midline Glioma (DMG) is a fatal brain stem glioma arising in young children. There are no effective therapies for DIPG and children typically succumb to the disease within 2 years. No therapy to-date has improved the survival rate for children with DIPG ...

Comparative Proteomic and RNA Sequencing of DIPGs

Scientific Merit: Pediatric diffuse intrinsic pontine gliomas (DIPGs) are high-grade cancers of the brainstem that are rarely biopsied due to the morbidity of the procedure.  Recent advances in the understanding of DIPG biology include the discovery of a mutation in the gene coding for histone 3.3 (H3.3K27M).  ...

Radiosensitisation of Diffuse Intrinsic Pontine Glioma by modulating the glucose ...

Diffuse Intrinsic Pontine Glioma (DIPG) is the most aggressive of all childhood cancers and the leading cause of brain tumour-related death in children. It accounts for 80% of all brainstem gliomas in children, with about 20-30 new diagnoses in Australia and 200-300 cases in the United States each year. There is ...

PI3K Signaling effectors in diffuse intrinsic pontine glioma

We propose two aims that will further understanding of the role of the phosphatidyl inositol-3 kinase (PI3K) pathway in diffuse intrinsic pontine gliomas (DIPG), and will impact therapy by providing insights needed for logical therapeutic use of Pl3K inhibitors for DIPG. The proposal builds on several strengths, including ...

Developing Novel Combination theraputic approaches for DIPG targeting Polo-like Kinase 1

Whole genome sequencing on DIPG biopsy and autopsy samples have identified specific mutations in Histone H3, ACVRI, TP53 and ATRX causing heterochromatin silencing, genetic instability and alterations in DNA damage response pathways. Using a unique panel of patient derived DIPG cultures, we have further examined the molecular profile of DIPG ...