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Results: 152

Targeting mitochondria-lysosome crosstalk as a therapeutic strategy for glioblastoma multiforme

Glioblastoma is the most common brain tumor. It is aggressive, and the therapeutic strategies focused on surgery, radiotherapy and chemotherapy are unable to destroy the tumor, which typically reappears post-treatment. The regrowth happens because the treatments are not able to destroy the cells that originate the tumor, called glioblastoma stem ...

Precision Therapy to Overcome Chemoresistance in Pediatric Glioblastoma

Glioblastoma (GBM) remains one of the most aggressive and lethal forms of cancer. Despite the best available treatment options including surgical resection, radiotherapy, and chemotherapy, prognosis is poor in glioblastoma, with a median overall survival of 14 months.1Currently, temozolomide (TMZ) is the preferred chemotherapeutic drug in the treatment of GBM ...

Targeting hypoxia and mitochondrial metabolism with repurposing drugs as an ...

Abstract Diffuse intrinsic pontine glioma (DIPG) is a rare and incurable brain tumor that arises in the brainstem of children predominantly between the ages of 6 and 9.  Unlike many brain tumors, DIPGs cannot be removed through surgery due to its sensitive location. The standard of care today remains radiation therapy (...

Exploiting the use of exosomal miRNAs from DIPG/DMG liquid ...

An unmet need in DIPG/DMG, is  the lack of reliable biomarkers. Those are urgently needed as alternative/complementary approach to neuroradiological imaging, not only for diagnosis but for disease monitoring. In this context, liquid biopsy could represent a valuable, non-invasive source for biomarkers in DIPG/DMG. From previous ...

Phase II trial of molecularly determined treatment of children and ...

Scientific Merit: The prognosis of diffuse intrinsic pontine gliomas (DIPGs) has not improved significantly over the last 40 years.  A major reason for this limitation is the lack of an understanding of the underlying biology of these tumors, as well as the absence of appropriate targets for therapeutic intervention.  ...