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Results: 218

Increased Tenascin-C (TNC) protein expression in tumor tissue and CSF ...

Innovation: Diffuse intrinsic pontine glioma (DIPG) is the most deadly solid tumor in children, with rapid progression, poor response to therapy, and average survival less than one year from diagnosis.  We describe a hypothesis-driven research plan to elucidate the mechanism by which Tenascin-C (TNC), an extracellular matrix (ECM) protein ...

Targeting neuronal activity-regulated DIPG infiltration (2015)

DIPG is characteristically infiltrative (i.e. diffuse and intrinsic), and this infiltrative/invasive behavior is destructive both in the brainstem and in other areas of the central nervous system to which DIPG spreads during the course of the disease. In work previously funded by the Cure Starts Now and the ...

PI3K Signaling effectors in diffuse intrinsic pontine glioma

We propose two aims that will further understanding of the role of the phosphatidyl inositol-3 kinase (PI3K) pathway in diffuse intrinsic pontine gliomas (DIPG), and will impact therapy by providing insights needed for logical therapeutic use of Pl3K inhibitors for DIPG. The proposal builds on several strengths, including ...

Precision Therapy to Overcome Chemoresistance in Pediatric Glioblastoma

Glioblastoma (GBM) remains one of the most aggressive and lethal forms of cancer. Despite the best available treatment options including surgical resection, radiotherapy, and chemotherapy, prognosis is poor in glioblastoma, with a median overall survival of 14 months.1Currently, temozolomide (TMZ) is the preferred chemotherapeutic drug in the treatment of GBM ...

Epigenetic Targeted Therapy and Resistance in AT/RT

Pediatric rhabdoid tumor in the brain, atypical teratoid/rhabdoid tumor (AT/RT), is a highly malignant brain tumor that has a very poor prognosis despite aggressive treatment. The development of new, effective therapeutic approaches for AT/RT has been hindered by a lack of specific therapeutic targets. It is necessary ...