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Results: 161

Unlocking the translational potential of the DIPG epigenome for a ...

Diffuse intrinsic pontine glioma (DIPG) is a malignant pediatric brain tumor with a very poor outlook, with an expected survival of one year. Lack of access to biological tissue sample continues to be the largest barrier to advancing treatment. In 2016, the World Health Organization (WHO) reclassified DIPG tumors as diffuse ...

Therapeutic targeting of NTRK2 rearrangements in diffuse midline glioma

Lay Summary   Diffuse midline glioma (DMG) is a malignant brain tumour arising in children representing a major unmet clinical need, with a 2-year survival rate close to zero. We recently discovered a proportion of children with DMG to have small genetic alterations in a gene called NTRK2. Although not ...

Epigenetic Regulation of Cell Fate Reprogramming in H3K27M-altered ...

Diffuse midline glioma, including those located at the pons in the brainstem (diffuse intrinsic pontine gliomas, DIPGs) are childhood brain tumors and patients with DIPG have a poor prognosis with a median survival time less than 1 year from diagnosis. Currently, apart from radiation therapy, which partially slows down tumor growth, ...

OLIG2 Targeting in DIPG using the novel small molecular inhibitor ...

Diffuse Intrinsic Pontine Glioma (DIPG) is an incurable brain stem glioma predominantly arising in young children, better options to treat this aggressive disease are urgently needed. Oligodendrocyte transcription factor 2 (OLIG2) is mostly expressed in restricted domains of the brain and spinal cord ventricular zone which give rise to oligodendrocytes and ...

Clinical, radiologic, and molecular characteristics of anaplastic pleomorphic xanthoastrocytomas

  Pleomorphic xanthoastrocytomas (PXAs) are uncommon brain cancers in children and young adults. World Health Organization (WHO) grade II PXAs (low-grade gliomas), which account for most such tumors, can be cured by complete surgery. Aggressive variants (i.e., anaplastic PXAs), which are rare, were only recognized by the WHO classification ...