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Results: 51

Determine the efficacy of BMP and MEK inhibitors with RT ...

We and others co-discovered the presence of activating mutations in ACVR1 in 25% of human DIPGs in 2014. Subsequently, my laboratory has developed a murine DIPG model incorporating R206H ACVR1 and observed that R206H ACVR1 significantly accelerates brainstem gliomagenesis. In addition, short-term treatment with a bone morphogenetic protein pathway inhibitor (...

Polyamine pathway metabolism as a novel therapeutic option for Diffuse ...

Diffuse intrinsic pontine glioma (DIPG) is the most aggressive of all childhood cancers. Standard treatment with radiotherapy is only palliative and chemotherapy has been found ineffective. Polyamines are organic compounds essential for key functions of living cells. They can be made by human cells but also generated from intestinal microorganisms ...

study of radiotherapy and concurrent bevacizumab temozolamide followed by bevacizumab. ...

Five-year overall survival in children with high-grade glioma (HGG) and diffuse, intrinsic brainstem glioma (DIPG) are approximately 25% and 10%, respectively 1-3. Achieving cure for all children with HGG and DIPG remains a major goal of pediatric neuro-oncology. DIPGs are infiltrative gliomas, and have typically been found to be &...

Investigating the role of DIPG-derived exosomes in tumor growth and ...

Diffuse Intrinsic Pontine Glioma (DIPG) is a highly aggressive and infiltrating brain tumor affecting children for which there is no effective treatment. Sequencing data have revealed the existence of well defined subgroups of tumors based on age of onset, specific location in the brain, mutations and clinical outcome. Those ...

MRI Guided Focused Ultrasound: Targeted Drug Delivery in Diffuse Intrinsic ...

Hypothesis & Anticipated Results Diffuse Intrinsic Pontine Glioma, (DIPG) is a fatal cancer and the leading cause of death from brain tumours in young children. Despite numerous existing chemotherapeutic agents and promising new molecular therapies, one overriding challenge remains: to overcome the blood brain barrier (BBB) and ...

Acute Lymphoblastic Leukemia (ALL)
Acute Myeloid Leukemia (AML)
Adrenocortical Carcinoma
AIDS-Related Lymphoma (Lymphoma)
Anal Cancer
Astrocytomas, Childhood (Brain Cancer)
Atypical Teratoid/Rhabdoid Tumor, Childhood (Brain Cancer)
Bile Duct Cancer
Bladder Cancer
Bone Cancer (includes Ewing Sarcoma and Osteosarcoma and Malignant Fibrous Histiocytoma)
Brain Tumors (General)
Breast Cancer
Carcinoid Tumor (Gastrointestinal)
Carcinoma of Unknown Primary
Cervical Cancer
Chronic Lymphocytic Leukemia (CLL)
Chronic Myelogenous Leukemia (CML)
Chronic Myeloproliferative Neoplasms
Colorectal Cancer
Craniopharyngioma, Childhood (Brain Cancer)
DIPG, Childhood (Brain Cancer)
Embryonal Tumors, Childhood (Brain Cancer)
Endometrial Cancer (Uterine Cancer)
Ependymoma, Childhood (Brain Cancer)
Esophageal Cancer
Ewing Sarcoma (Bone Cancer)
Extracranial Germ Cell Tumor, Childhood
Extragonadal Germ Cell Tumor
Eye Cancer
Fallopian Tube Cancer
Fibrous Histiocytoma of Bone, Malignant, and Osteosarcoma
Gallbladder Cancer
Gastric (Stomach) Cancer
Gastrointestinal Carcinoid Tumors
Gastrointestinal Stromal Tumors (GIST) (Soft Tissue Sarcoma)
Germ Cell Tumors
Gestational Trophoblastic Disease
Hepatocellular (Liver) Cancer
Histiocytosis, Langerhans Cell
Hodgkin Lymphoma
Hypopharyngeal Cancer
Intraocular Melanoma
Islet Cell Tumors, Pancreatic Neuroendocrine Tumors
Kaposi Sarcoma (Soft Tissue Sarcoma)
Kidney (Renal Cell) Cancer
Langerhans Cell Histiocytosis
Laryngeal Cancer (Head and Neck Cancer)
Leukemia
Lip and Oral Cavity Cancer (Head and Neck Cancer)
Liver Cancer
Lung Cancer (Non-Small Cell and Small Cell)
Lymphoma
Male Breast Cancer
Malignant Fibrous Histiocytoma of Bone and Osteosarcoma
Medulloblastoma, Childhood (Brain Cancer)
Melanoma
Melanoma, Intraocular (Eye)
Merkel Cell Carcinoma (Skin Cancer)
Mesothelioma, Malignant
Metastatic Cancer
Metastatic Squamous Neck Cancer with Occult Primary (Head and Neck Cancer)
Mouth Cancer (Head and Neck Cancer)
Multiple Myeloma/Plasma Cell Neoplasms
Mycosis Fungoides (Lymphoma)
Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Neoplasms
Myelogenous Leukemia, Chronic (CML)
Myeloid Leukemia, Acute (AML)
Myeloproliferative Neoplasms, Chronic
Nasal Cavity and Paranasal Sinus Cancer (Head and Neck Cancer)
Nasopharyngeal Cancer
Neuroblastoma
Non-Hodgkin Lymphoma
Non-Small Cell Lung Cancer
Oral Cancer, Lip and Oral Cavity Cancer and Oropharyngeal Cancer (Head and Neck Cancer)
Oropharyngeal Cancer
Osteosarcoma (Bone Cancer)
Ovarian Cancer
Pancreatic Cancer
Pancreatic Neuroendocrine Tumors (Islet Cell Tumors)
Paraganglioma
Paranasal Sinus and Nasal Cavity Cancer (Head and Neck Cancer)
Parathyroid Cancer
Penile Cancer
Pharyngeal Cancer (Head and Neck Cancer)
Pheochromocytoma
Pituitary Tumor
Plasma Cell Neoplasm/Multiple Myeloma
PNET, Childhood (Brain Cancer)
Pregnancy and Breast Cancer
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Prostate Cancer
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Recurrent Cancer
Renal Cell (Kidney) Cancer
Retinoblastoma
Rhabdomyosarcoma, Childhood (Soft Tissue Sarcoma)
Salivary Gland Cancer (Head and Neck Cancer)
Sarcoma
Skin Cancer
Small Cell Lung Cancer
Small Intestine Cancer
Soft Tissue Sarcoma
Squamous Neck Cancer with Occult Primary, Metastatic (Head and Neck Cancer)
Stomach (Gastric) Cancer
Testicular Cancer
Throat Cancer (Head and Neck Cancer)
Thymoma and Thymic Carcinoma
Thyroid Cancer
Transitional Cell Cancer of the Renal Pelvis and Ureter (Kidney (Renal Cell) Cancer)
Ureter and Renal Pelvis, Transitional Cell Cancer (Kidney (Renal Cell) Cancer
Urethral Cancer
Uterine Cancer, Endometrial
Uterine Sarcoma
Vaginal Cancer
Vascular Tumors (Soft Tissue Sarcoma)
Vulvar Cancer
Wilms Tumor and Other Childhood Kidney Tumors