Grant Search

Cancer Type

Keyword Search  

Categories

Grant Amount
>=

<=





Results: 138

Repurposing antimalarial drugs for DIPG therapy

Diffuse intrinsic pontine gliomas (DIPGs) are rare but highly aggressive brain tumors found in the pons, an area of the brainstem that controls many of the body’s most vital functions such as breathing, blood pressure, and heart rate. Despite DIPG being the leading cause of pediatric death by ...

Pilot Trial to Evaluate the Feasibility and Clinical Utility of ...

Abstract: Outcomes in children with solid tumors that are already spread at the time of diagnosis or that do not respond with chemotherapy are generally poor and attempts to intensify treatment have not improved survival.  Personalized medicine is an emerging field of medicine that uses genetic information obtained from ...

Exploring the brain-gut-microbiota axis to characterize and predict outcome in ...

Abstract Diffuse intrinsic pontine gliomas (DIPGs), represent a group of malignancies with rapid onset of devastating neurologic symptoms associated with the local extension, poor response to adjuvant therapy and a very poor prognosis. Radiotherapy has remained the only modality of treatment with proven transient symptomatic improvement and represents the mainstay ...

Enhancing response to radiation therapy by increasing tumor oxygenation in ...

The survival time for patients with pediatric high-grade glioma (pHGG) remains devastatingly short, in large part because pHGG tumors become resistant to radiation, the only available therapy with confirmed efficacy. This radioresistance is triggered by regions of hypoxia (low oxygen) that develop within the tumor as it grows. We found ...

Modulating the DIPG microenvironment with virus and complement inhibitors as ...

Diffuse intrinsic pontine glioma (DIPG) is one of the most formidable challenges faced by pediatric oncologists. For the last 30 years, all treatment approaches for these type of tumors have failed, leaving a terrible prospect of survival at 5 years for these children virtually of zero. Thus, it is clear that new ...