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Results: 152

Targeting a novel mitochondrial apoptotic pathway in Neuroblastoma

Mitochondria are subcellular, double-membrane organelles. From a functional point of view they can be considered as hubs where cellular energy metabolism and cell death signalling converge and are finely regulated. Functional mitochondria are essential for cancer cells. Many of the agents with anti-cancer activity that act on Mitochondria (Mi), hold ...

Treatment of Diffuse Intrinsic Pontine Glioma with the Oncolytic Zika ...

Diffuse intrinsic pontine glioma (DIPG) is a devastating brainstem tumor affecting 150-300 children in the US per year. The overall rate of survival is dismal, with only 10% of children surviving beyond the second year from the time of diagnosis.[1]  Though a rare tumor with high mortality, DIPG represents 80% of ...

Testing cytotoxic effects and deciphering signalling pathways engaged by a ...

Glioblastoma (GBM) is the most common malignant brain tumor, being highly invasive and not responsive to standard treatment (surgery, radiotherapy, and chemotherapy). Moreover, a major determinant of the high lethality of GBM is the presence of self-renewing, tumorigenic glioblastoma stem-like cells (GSCs) that threateningly support the development and the progressive ...

MiR181 as novel biomarkers in precision medicine of Bile Duct ...

Bile Tract Cancers (BTC) include cholangiocarcinoma (CCA) and gallbladder cancer (GBC) and their incidence is increasing worldwide [1, 2] . Lack of effective radical treatments highlights the need for a better understanding of BTC biology and mechanisms of response to treatment [1, 2]. Eighty-percent of BTC patients present at an advanced stage, when treatment options ...

A new hope: targeting the oncogenic driver H3K27M ...

Diffuse midline gliomas (DMG) and diffuse intrinsic pontine gliomas (DIPG) are devastating pediatric tumors that urgently require effective treatment options. The discovery of H3K27M as a key driver of DMG has brought newfound hope to the field of pediatric oncology, however, the unavailability of a suitable drug to ...