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Results: 138

OLIG2 Targeting in DIPG using the novel small molecular inhibitor ...

Diffuse Intrinsic Pontine Glioma (DIPG) is an incurable brain stem glioma predominantly arising in young children, better options to treat this aggressive disease are urgently needed. Oligodendrocyte transcription factor 2 (OLIG2) is mostly expressed in restricted domains of the brain and spinal cord ventricular zone which give rise to oligodendrocytes and ...

Clinical, radiologic, and molecular characteristics of anaplastic pleomorphic xanthoastrocytomas

  Pleomorphic xanthoastrocytomas (PXAs) are uncommon brain cancers in children and young adults. World Health Organization (WHO) grade II PXAs (low-grade gliomas), which account for most such tumors, can be cured by complete surgery. Aggressive variants (i.e., anaplastic PXAs), which are rare, were only recognized by the WHO classification ...

Precision Therapy to Overcome Chemoresistance in Pediatric Glioblastoma

Glioblastoma (GBM) remains one of the most aggressive and lethal forms of cancer. Despite the best available treatment options including surgical resection, radiotherapy, and chemotherapy, prognosis is poor in glioblastoma, with a median overall survival of 14 months.1Currently, temozolomide (TMZ) is the preferred chemotherapeutic drug in the treatment of GBM ...

Modulation of intra-tumor hypoxia to sensitize DIPG irradiation and initiate ...

Malignant gliomas in specific region like brain pons are not curable as they cannot be surgically resected and are only transiently benefiting from local irradiation and in some cases from targeted therapies. These aggressive brain tumors are molecularly well known as they are characterized by a driver mutation. This abnormality ...

Targeting mitochondria-lysosome crosstalk as a therapeutic strategy for glioblastoma multiforme

Glioblastoma is the most common brain tumor. It is aggressive, and the therapeutic strategies focused on surgery, radiotherapy and chemotherapy are unable to destroy the tumor, which typically reappears post-treatment. The regrowth happens because the treatments are not able to destroy the cells that originate the tumor, called glioblastoma stem ...