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Results: 218

National expansion of the study of radiotherapy and concurrent bevacizumab ...

Five-year overall survival in children with high-grade glioma (HGG) and diffuse, intrinsic brainstem glioma (DIPG) are approximately 25% and 10%, respectively1-3.  Achieving cure for all children with HGG and DIPG remains a major goal of pediatric neuro-oncology. DIPGs are infiltrative gliomas, and have typically been found to be  high-grade ...

Development of peptide vaccine for diffuse intrinsic pontine glioma Executive ...

Hypothesis- Our hypothesis is that a peptide vaccination targeting H3.3K27M will be an effective tumor-specific therapy for patients with gliomas expressing this mutation, without antigen escape or toxicity.    Goals- To identify an effective therapy that will prolong the survival of children with DIPG. We will pursue ...

Preclinical evaluation of systemic and direct delivery of a PDGFR-alpha ...

Hypothesis- Genetically engineered mouse models of cancer are useful to elucidate mechanisms of tumorigenesis, and can serve as preclinical models for the evaluation of novel agents.  Rare tumors such as brainstem gliomas (BSGs) require genetically accurate preclinical models, which recapitulate the genetic alterations seen in the human disease, as ...

POLYAMINE PATHWAY METABOLISM AS A NOVEL THERAPEUTIC OPTION FOR DIFFUSE ...

Diffuse intrinsic pontine glioma (DIPG) is the most aggressive of all childhood cancers. Standard treatment with radiotherapy is only palliative and chemotherapy has been found ineffective. Polyamines are organic compounds essential for key functions of living cells. They can be made by human cells but also generated from intestinal microorganisms ...

Increased Tenascin-C (TNC) protein expression in tumor tissue and CSF ...

Innovation: Diffuse intrinsic pontine glioma (DIPG) is the most deadly solid tumor in children, with rapid progression, poor response to therapy, and average survival less than one year from diagnosis.  We describe a hypothesis-driven research plan to elucidate the mechanism by which Tenascin-C (TNC), an extracellular matrix (ECM) protein ...

Targeting neuronal activity-regulated DIPG infiltration (2015)

DIPG is characteristically infiltrative (i.e. diffuse and intrinsic), and this infiltrative/invasive behavior is destructive both in the brainstem and in other areas of the central nervous system to which DIPG spreads during the course of the disease. In work previously funded by the Cure Starts Now and the ...