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Results: 139

Investigating the genomic blueprint of invasive and treatment-resistant tumor cells ...

Diffuse intrinsic pontine gliomas (DIPG) are incurable tumours that account for nearly 10% of all pediatric brain cancers. Current therapies are ineffective and the median survival remains under a year with near 100% fatality.  Understanding how DIPG tumour cells evolve to withstand selective pressures and become incurable entities is key ...

Targeting receptor tyrosine kinase signalling pathways in DIPG by using ...

Diffuse Intrinsic Pontine Glioma (DIPG) is the most dismal paediatric brain tumour, characterised by universal mortality and an average survival of less than one year. Several factors contribute to the unique challenges in treating DIPG, including localisation, infiltrative pattern of growth and chemoresistance. Treatment options are limited to palliative radiotherapy. ...

Exploring Combination Therapy for DIPG: SGI-110 and GAA Vaccine

Diffuse intrinsic pontine glioma (DIPG) are some of the deadliest childhood brain tumors. The immune system protects the body by recognizing targets on harmful cells, but tumor cells can “switch off” the targets and hide from the immune system. We have been using a vaccine that can target ...

Targeting the thioredoxin system as a novel strategy for DIPG

Diffuse intrinsic pontine glioma (DIPG) is the most aggressive of all childhood brain cancers. Radiotherapy treatment is palliative, and chemotherapy is ineffective. We have found that both DIPG cells and DIPG animal models are exquisitely sensitive to auranofin. Auranofin is a gold containing anti-inflammatory compound previously used to treat rheumatoid ...

Development of immunocompetent animal models for pediatric high-grade glioma and ...

Brain tumors are the leading cause of cancer-related death in children, with high-grade glioma (pHGG) and diffuse intrinsic pontine glioma (DIPG) carrying the worst prognosis, with no chance of cure. Over the past years, the prognosis of other aggressive cancer types has improved thanks to scientific breakthroughs in the field ...