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Results: 185

SARS-CoV-2 infection in brain cancer children: clinical characteristics and transmission ...

As at end of May 2020, Italy is one of the country’s most affected by COVID-19 worldwide, with ~230k cases and ~34k deaths attributed to the virus. The Milan area, being one of the epicenters of the Italian epidemic, is experiencing significant pressure on its health system, impacting the ...

Pilot Trial to Evaluate the Feasibility and Clinical Utility of ...

Abstract: Outcomes in children with solid tumors that are already spread at the time of diagnosis or that do not respond with chemotherapy are generally poor and attempts to intensify treatment have not improved survival.  Personalized medicine is an emerging field of medicine that uses genetic information obtained from ...

Enhancing response to radiation therapy by increasing tumor oxygenation in ...

The survival time for patients with pediatric high-grade glioma (pHGG) remains devastatingly short, in large part because pHGG tumors become resistant to radiation, the only available therapy with confirmed efficacy. This radioresistance is triggered by regions of hypoxia (low oxygen) that develop within the tumor as it grows. We found ...

Targeting a novel mitochondrial apoptotic pathway in Neuroblastoma

Mitochondria are subcellular, double-membrane organelles. From a functional point of view they can be considered as hubs where cellular energy metabolism and cell death signalling converge and are finely regulated. Functional mitochondria are essential for cancer cells. Many of the agents with anti-cancer activity that act on Mitochondria (Mi), hold ...

MiR181 as novel biomarkers in precision medicine of Bile Duct ...

Bile Tract Cancers (BTC) include cholangiocarcinoma (CCA) and gallbladder cancer (GBC) and their incidence is increasing worldwide [1, 2] . Lack of effective radical treatments highlights the need for a better understanding of BTC biology and mechanisms of response to treatment [1, 2]. Eighty-percent of BTC patients present at an advanced stage, when treatment options ...