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Results: 178

SUMOylation as a novel therapeutic target in DIPG

Post-translational protein modification (PTM) is one of the important  mechanisms by which the function of cellular proteins are modulated.  SUMOylation is a  reversible PTM which has emerged as a crucial molecular  mechanism, involved in the control of DNA damage repair, immune responses, carcinogenesis, cell  division ...

Targeting the thioredoxin system as a novel strategy for DIPG

Diffuse intrinsic pontine glioma (DIPG) is the most aggressive of all childhood brain cancers. Radiotherapy treatment is palliative, and chemotherapy is ineffective. We have found that both DIPG cells and DIPG animal models are exquisitely sensitive to auranofin. Auranofin is a gold containing anti-inflammatory compound previously used to treat rheumatoid ...

Exploring Combination Therapy for DIPG: SGI-110 and GAA Vaccine

Diffuse intrinsic pontine glioma (DIPG) are some of the deadliest childhood brain tumors. The immune system protects the body by recognizing targets on harmful cells, but tumor cells can “switch off” the targets and hide from the immune system. We have been using a vaccine that can target ...

SARS-CoV-2 infection in brain cancer children: clinical characteristics and transmission ...

As at end of May 2020, Italy is one of the country’s most affected by COVID-19 worldwide, with ~230k cases and ~34k deaths attributed to the virus. The Milan area, being one of the epicenters of the Italian epidemic, is experiencing significant pressure on its health system, impacting the ...

Glycan Signatures of Resistance in Diffuse Intrinsic Pontine Glioma (DIPG)

Diffuse intrinsic pontine glioma (DIPG) is a brain tumor that primarily affects young children ages 5-9 and claims nearly all its victims in less than 2 years. DIPG tumors are located in the brainstem, rendering them inoperable, and radiation, the only FDA-approved treatment, inevitably results in recurrence as tumor cells develop ...