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Results: 218

Targeting DIPGs through Super-activation of Steroid Receptor Co-activators: An in ...

The objective of this application is to determine if combining ionizing radiation with the newly-described steroid receptor co-activator (SRC) small molecule stimulator MCB-613 will lead to enhanced tumor cell killing and significantlyimproved therapeutic efficacyin vivo in patient tumor-derived orthotopic xenograft (PDOX) mouse models of diffuse intrinsic pontine glioma (DIPG). DIPG ...

Investigating the role of DIPG-derived exosomes in tumor growth and ...

Diffuse intrinsic pontine glioma (DIPG) is a devastating brain tumor which affects children and for which there is no effective treatment at the moment.  We and others have recently shown that DIPG is characterized by a remarkable degree of intratumoral heterogeneity and consists of distinct genetically and phenotypically heterogeneous ...

Radiosensitisation of Diffuse Intrinsic Pontine Glioma by modulating the glucose ...

Diffuse Intrinsic Pontine Glioma (DIPG) is the most aggressive of all childhood cancers and the leading cause of brain tumour-related death in children. It accounts for 80% of all brainstem gliomas in children, with about 20-30 new diagnoses in Australia and 200-300 cases in the United States each year. There is ...

Allele-specific antisense therapy for DIPG

Diffuse intrinsic pontine glioma (DIPG) mainly affects very young children and has the highest mortality of all pediatric solid tumors. The median survival is only 9 months, with most patients dying within 2 years after the initial diagnosis. The clinical management of DIPG is a major challenge in pediatric neuro-oncology. The tumor'...

Exploring the interactome of H3K27M to find theraputic ...

We now have a wealth of genetic and epigenetic information about DIPG. However, relatively little is known about the molecular consequences downstream from H3K27M mutations and how they can lead to cancer formation. It is known that, as well as DNA hypomethylation, H3K27M mutation leads to ...

Mitochondrial DNA alterations and their potential as a novel therapeutic ...

Brain tumors are the leading cause of cancer-related death in childhood. Diffuse intrinsic pontine glioma (DIPG) arises in the pons of the brainstem and is universally fatal, comprising nearly 15% of all pediatric brain tumors.1 Despite international endeavors to improve outcome, DIPGs show poor response to conventional radiation and chemotherapeutic strategies ...