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Results: 86

The current situation of childhood brain tumor long-term survivors in ...

Central nervous system tumors, represent the highest mortality rate of all childhood malignancies, Nevertheless, the number of survivors of pediatric Brain tumors continues to increase. Gradually improving survival rates and a growing population of long-term survivors have expanded the focus of research, Increased attention has been given to late ...

Interaction of Immune System with Oncolytic Measles Virus Therapy of ...

Medulloblastoma (MB) is the most common malignant brain tumor in children. The Group 3 MB patients have the worst prognosis and dismal 5-year survival rate among the four distinct subtypes of MB: WNT, SHH, Group 3 and Group 4 tumors. Sadly, MB survivors face life-long debilitating neurocognitive side effects from craniospinal radiation that ...

Enhancing response to radiation therapy by increasing tumor oxygenation in ...

The survival time for patients with pediatric high-grade glioma (pHGG) remains devastatingly short, in large part because pHGG tumors become resistant to radiation, the only available therapy with confirmed efficacy. This radioresistance is triggered by regions of hypoxia (low oxygen) that develop within the tumor as it grows. We found ...

Targeting Glycolysis for Inhibition of Tumor Growth in Pediatric Brain ...

Pediatric brain tumors have limited responses to conventional therapeutic option and high mortality rates. Novel approaches to treat these and other forms of cancer involve targeting metabolic mechanisms of cancer cells from which they derive energy. These include aerobic glycolysis or the Warburg effect; named after Otto Warburg who first ...

Multi-modal Epigenetic Pt(IV) Prodrugs for Paediatric High Grade Gliomas

Diffuse intrinsic pontine gliomas (DIPG) are highly aggressive cancers - DIPG has a survival rate of 1% at 5 years. Platinum(II) anti-cancer drugs (e.g. carboplatin) are used in combination with sodium valproate to treat DIPG clinically, with the intact blood brain barrier being effectively bypassed by convection enhanced delivery. We ...