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Results: 85

Glycomic Tumor Neoantigen Discovery in Diffuse Intrinsic Pontine Glioma (DIPG)

Diffuse intrinsic pontine glioma (DIPG) is a horrific childhood brain cancer. Patients die within 2 years of diagnosis. Treatments include radio- and chemotherapy, however the tumor always regrows due to resistance of the tumor cells to therapy. Understanding and tackling resistance is key to improve survival of patients with DIPG. We ...

SARS-CoV-2 infection in brain cancer children: clinical characteristics and transmission ...

As at end of May 2020, Italy is one of the country’s most affected by COVID-19 worldwide, with ~230k cases and ~34k deaths attributed to the virus. The Milan area, being one of the epicenters of the Italian epidemic, is experiencing significant pressure on its health system, impacting the ...

Epigenetic Targeted Therapy and Resistance in AT/RT

Pediatric rhabdoid tumor in the brain, atypical teratoid/rhabdoid tumor (AT/RT), is a highly malignant brain tumor that has a very poor prognosis despite aggressive treatment. The development of new, effective therapeutic approaches for AT/RT has been hindered by a lack of specific therapeutic targets. It is necessary ...

A novel CRISPR/Cas9 approach to target the EWS-FLI1 fusion ...

Ewing’s sarcoma (EWS) is a devastating pediatric cancer of bone and soft tissues where the treatments used are typically very toxic, resulting in profound morbidities. Furthermore, these intense and non-specific treatments often lead to secondary tumors later in life. Thus, a less toxic and more specific treatment is ...

Pilot Trial to Evaluate the Feasibility and Clinical Utility of ...

Abstract: Outcomes in children with solid tumors that are already spread at the time of diagnosis or that do not respond with chemotherapy are generally poor and attempts to intensify treatment have not improved survival.  Personalized medicine is an emerging field of medicine that uses genetic information obtained from ...