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Results: 16

POLYAMINE PATHWAY METABOLISM AS A NOVEL THERAPEUTIC OPTION FOR DIFFUSE ...

Diffuse intrinsic pontine glioma (DIPG) is the most aggressive of all childhood cancers. Standard treatment with radiotherapy is only palliative and chemotherapy has been found ineffective. Polyamines are organic compounds essential for key functions of living cells. They can be made by human cells but also generated from intestinal microorganisms ...

Targeting neuronal activity-regulated DIPG infiltration (2015)

DIPG is characteristically infiltrative (i.e. diffuse and intrinsic), and this infiltrative/invasive behavior is destructive both in the brainstem and in other areas of the central nervous system to which DIPG spreads during the course of the disease. In work previously funded by the Cure Starts Now and the ...

COllaborative Network for NEurooncology Clinical Trials (CONNECT)

CONNECT’s goal is to establish an international clinical trials collaboration for the conduct of scientificallrational, pilot studies to assess feasibility and early efficacy of incorporating promising novel agents testablished frontline therapeutic regimens in children with newly-diagnosed, high-risk brain tumors. Thicollaboration builds on the existing infrastructure and partnerships established ...

BMP and MAPK Inhibition

We and others co-discovered the presence of activating mutations in ACVR1 in 25% of human DIPGs in 2014. Subsequently, my laboratory has developed a murine DIPG model incorporating R206H ACVR1 and observed that R206H ACVR1 significantly accelerates brainstem gliomagenesis. In addition, short-term treatment with a bone morphogenetic protein pathway inhibitor (...

Imaging to Discern Immunotherapeutic-Induced Pseudoprogression in CNS Tumors

Brain tumors are the most common cause of childhood deaths by disease in the United States. Even when standard treatments successfully eliminate tumors, they often bestow devastating long-term effects, including an increased risk for the development of secondary cancers, without guaranteed prevention of relapse. ...