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Results: 161

Epigenetic reprogramming as a treatment option for NF1

Neurofibromatosis type 1 (NF1) is common, occurring in 1/3000 live births, and results in skin pigmentation and the growth of tumors along nerves in the skin, brain, and other parts of the body. It arises from a mutated and non-functional tumor suppressor bearing its name.  Tumors of the peripheral nerves, called ...

Targeting receptor tyrosine kinase signalling pathways in DIPG by using ...

Diffuse Intrinsic Pontine Glioma (DIPG) is the most dismal paediatric brain tumour, characterised by universal mortality and an average survival of less than one year. Several factors contribute to the unique challenges in treating DIPG, including localisation, infiltrative pattern of growth and chemoresistance. Treatment options are limited to palliative radiotherapy. ...

Investigating the genomic blueprint of invasive and treatment-resistant tumor cells ...

Diffuse intrinsic pontine gliomas (DIPG) are incurable tumours that account for nearly 10% of all pediatric brain cancers. Current therapies are ineffective and the median survival remains under a year with near 100% fatality.  Understanding how DIPG tumour cells evolve to withstand selective pressures and become incurable entities is key ...

Chromatin defects and therapeutic targets in pediatric brain cancers

DNA is wrapped around an octamer of histone proteins, known as a nucleosome, to form the basic repeating unit of chromatin. Genes encoding two chromatin regulators, ATRX and the histone H3.3, are frequently mutated in pediatric glioblastoma (pGBM) which is a lethal form of brain cancer. To translate this new ...

The characterisation of diffuse midline gliomas/diffuse intrinsic pontine gliomas ...

High-grade gliomas are a rare group of tumours that can occur anywhere within the central nervous system (brain and spinal cord). They have a dismal prognosis, usually with a < 2 year survival after diagnosis and therefore represent a significant clinical challenge. Diffuse midline gliomas (DMG) and diffuse intrinsic pontine gliomas (...