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Results: 192

Starve the monster: Investigation of multi-metabolic treatment strategies for H3.3...

Diffuse midline glioma (DMG) including diffuse intrinsic pontine glioma (DIPG) are most aggressive, deadly brain tumors of childhood with marked therapeutic resistance. DIPG/DMG are uniquely characterized by a histone mutation (H3K27M) that significantly contributes to the poor prognosis. In consequence, targeting H3K27M-mutation in DIPG/DMG ...

Targeting alpha-KG synthesis for the therapeutic intervention in DIPG

Diffuse intrinsic pontine glioma (DIPG) is an aggressive childhood brain tumor, accounting for 10% of all pediatric central nervous system tumors with the median overall survival of 10.5 months. Since DIPG tumors infiltrate brainstem and pons, they are inoperable because surgery in this location of the brain can lead into severe neurological ...

Comprehensive characterization of secreted RNA from Diffuse Midline Glioma (DMG)

Diffuse Midline Gliomas (DMG) are fatal childhood brain cancers. Current methods to diagnose and monitor DMG include brain imaging and biopsies; both of these approaches have limitations, and a non-invasive assay for DMG is critically needed. Exosomes are vesicles, secreted by cells, into bodily fluids, such as blood. These vesicles ...

Use of Artificial Intelligence-powered Müller Matrix Polarimetry to transform ...

This multidisciplinary project will investigate ways to improve management of pancreas cancer patients, by developing an analysis method called Müller Matrix Polarimetry (MMP) to diagnose cancers with greater detail. MMP distinguishes healthy and cancer cells by the way light is reflected differently by these tissues. Using MMP together ...

Developing the next generation of targeted epigenetic therapy in diffuse ...

Diffuse intrinsic pontine glioma (DIPG) is a tumour of the brainstem and is recognized as one of the most lethal of all cancers. Every year, about 150-300 children in the USA and 3,000 children worldwide are diagnosed with DIPG. The prognosis of DIPG is devastating as only 10% of the patients ...

Acute Lymphoblastic Leukemia (ALL)
Acute Myeloid Leukemia (AML)
Adrenocortical Carcinoma
AIDS-Related Lymphoma (Lymphoma)
Anal Cancer
Astrocytomas, Childhood (Brain Cancer)
Atypical Teratoid/Rhabdoid Tumor, Childhood (Brain Cancer)
Bile Duct Cancer
Bladder Cancer
Bone Cancer (includes Ewing Sarcoma and Osteosarcoma and Malignant Fibrous Histiocytoma)
Brain Tumors (General)
Breast Cancer
Carcinoid Tumor (Gastrointestinal)
Carcinoma of Unknown Primary
Cervical Cancer
Chronic Lymphocytic Leukemia (CLL)
Chronic Myelogenous Leukemia (CML)
Chronic Myeloproliferative Neoplasms
Colorectal Cancer
Craniopharyngioma, Childhood (Brain Cancer)
DIPG, Childhood (Brain Cancer)
Embryonal Tumors, Childhood (Brain Cancer)
Endometrial Cancer (Uterine Cancer)
Ependymoma, Childhood (Brain Cancer)
Esophageal Cancer
Ewing Sarcoma (Bone Cancer)
Extracranial Germ Cell Tumor, Childhood
Extragonadal Germ Cell Tumor
Eye Cancer
Fallopian Tube Cancer
Fibrous Histiocytoma of Bone, Malignant, and Osteosarcoma
Gallbladder Cancer
Gastric (Stomach) Cancer
Gastrointestinal Carcinoid Tumors
Gastrointestinal Stromal Tumors (GIST) (Soft Tissue Sarcoma)
Germ Cell Tumors
Gestational Trophoblastic Disease
Hepatocellular (Liver) Cancer
Histiocytosis, Langerhans Cell
Hodgkin Lymphoma
Hypopharyngeal Cancer
Intraocular Melanoma
Islet Cell Tumors, Pancreatic Neuroendocrine Tumors
Kaposi Sarcoma (Soft Tissue Sarcoma)
Kidney (Renal Cell) Cancer
Langerhans Cell Histiocytosis
Laryngeal Cancer (Head and Neck Cancer)
Leukemia
Lip and Oral Cavity Cancer (Head and Neck Cancer)
Liver Cancer
Lung Cancer (Non-Small Cell and Small Cell)
Lymphoma
Male Breast Cancer
Malignant Fibrous Histiocytoma of Bone and Osteosarcoma
Medulloblastoma, Childhood (Brain Cancer)
Melanoma
Melanoma, Intraocular (Eye)
Merkel Cell Carcinoma (Skin Cancer)
Mesothelioma, Malignant
Metastatic Cancer
Metastatic Squamous Neck Cancer with Occult Primary (Head and Neck Cancer)
Mouth Cancer (Head and Neck Cancer)
Multiple Myeloma/Plasma Cell Neoplasms
Mycosis Fungoides (Lymphoma)
Myelodysplastic Syndromes, Myelodysplastic/Myeloproliferative Neoplasms
Myelogenous Leukemia, Chronic (CML)
Myeloid Leukemia, Acute (AML)
Myeloproliferative Neoplasms, Chronic
Nasal Cavity and Paranasal Sinus Cancer (Head and Neck Cancer)
Nasopharyngeal Cancer
Neuroblastoma
Non-Hodgkin Lymphoma
Non-Small Cell Lung Cancer
Oral Cancer, Lip and Oral Cavity Cancer and Oropharyngeal Cancer (Head and Neck Cancer)
Oropharyngeal Cancer
Osteosarcoma (Bone Cancer)
Ovarian Cancer
Pancreatic Cancer
Pancreatic Neuroendocrine Tumors (Islet Cell Tumors)
Paraganglioma
Paranasal Sinus and Nasal Cavity Cancer (Head and Neck Cancer)
Parathyroid Cancer
Penile Cancer
Pharyngeal Cancer (Head and Neck Cancer)
Pheochromocytoma
Pituitary Tumor
Plasma Cell Neoplasm/Multiple Myeloma
PNET, Childhood (Brain Cancer)
Pregnancy and Breast Cancer
Primary Central Nervous System (CNS) Lymphoma
Primary CNS Lymphoma
Primary Peritoneal Cancer
Prostate Cancer
Rectal Cancer
Recurrent Cancer
Renal Cell (Kidney) Cancer
Retinoblastoma
Rhabdomyosarcoma, Childhood (Soft Tissue Sarcoma)
Salivary Gland Cancer (Head and Neck Cancer)
Sarcoma
Skin Cancer
Small Cell Lung Cancer
Small Intestine Cancer
Soft Tissue Sarcoma
Squamous Neck Cancer with Occult Primary, Metastatic (Head and Neck Cancer)
Stomach (Gastric) Cancer
Testicular Cancer
Throat Cancer (Head and Neck Cancer)
Thymoma and Thymic Carcinoma
Thyroid Cancer
Transitional Cell Cancer of the Renal Pelvis and Ureter (Kidney (Renal Cell) Cancer)
Ureter and Renal Pelvis, Transitional Cell Cancer (Kidney (Renal Cell) Cancer
Urethral Cancer
Uterine Cancer, Endometrial
Uterine Sarcoma
Vaginal Cancer
Vascular Tumors (Soft Tissue Sarcoma)
Vulvar Cancer
Wilms Tumor and Other Childhood Kidney Tumors