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Results: 178

Discovering new epigenetic players of DIPG (Application for an extension)

Diffuse intrinsic pontine glioma (DIPG) is the most aggressive brain tumour in children. Every year, about 150-300 children in the USA and 3,000 children worldwide are diagnosed with DIPG. The prognosis of DIPG is devastating as only 10% of the patients will live for more than two years1,2. In the ...

EphB3 controls DIPG invasion via regulation of glioma-to-neuron synaptogenesis

Diffuse Intrinsic Pontine Glioma (DIPG), is a highly aggressive, universally fatal brain stem glioma arising in young children.1 There are no effective therapies for DIPG and children typically succumb to the disease within two years of diagnosis.2 Previous studies have shown that DIPG tumours actively communicate with neurons, a phenomenon ...

Fenretinide, a novel agent targeting RTK/PI3K/AKT network ...

Diffuse Intrinsic Pontine Gliomas (DIPG) are the most aggressive of all childhood cancers.  They are a type of brain tumour that peak in incidence at 5-7 years of age and are the most common form of malignant glioma to affect children.  There are absolutely no effective treatments and ...

Investigating mechanisms of therapeutic resistance in DIPG

Brain tumors are the largest group of solid tumors and the leading cause of cancer-related deaths in childhood1. The most devastating of these is DIPG, an incurable tumor with a median survival of less than one year2,3.  DIPGs show poor response to conventional therapy and until recently we have ...

Targeting DIPG through combining a super-activator (MCB-613) of steroid receptor ...

The objective of this application is to demonstrate that combining MCB-613, a small molecule stimulator of the oncogenic steroid receptor co-activator (SRC), with ionizing radiation would synergistically kill tumor cells of diffuse intrinsic pontine glioma (DIPG) in vivo and significantly prolong survival times in patient tumor-derived orthotopic (intra-brain stem) xenograft (...