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Results: 192

Phase 2 Study of the MEK inhibitor MEKTOVI® (binimetinib) for the ...

This proposal is designed to help support a novel international clinical trial for children with the highly morbid brain tumor, Adamantinomatous Craniopharyngioma (ACP).  ACP is a solid/cystic tumor that originates in the sellar/suprasellar region at the base of the brain, adjacent to critical structures for vision, hormone ...

Exploring therapeutic options for BRCA-mutant DIPG

There is an urgent need for better therapies to treat patients with the most aggressive type of childhood cancer, Diffuse Intrinsic Pontine Glioma (DIPG). DIPG is an incurable brain cancer with 5-year survival of <1%. We have formed an international collaboration to find genetic causes of DIPG, and have made ...

Mapping DIPG Tumour Progression and understanding Biological Heterogeneity using Spatial ...

Diffuse Intrinsic Pontine Glioma (DIPG) otherwise known as Diffuse Midline Glioma (DMG) is a fatal brain stem glioma arising in young children. There are no effective therapies for DIPG and children typically succumb to the disease within 2 years. No therapy to-date has improved the survival rate for children with DIPG ...

Exploiting 3D Tumor Tissue Analogs to Elucidate the Role of ...

Diffuse intrinsic pontine glioma (DIPG) is a rare form of inoperable cancer arising in the brainstem of children, with poor response to chemotherapy and no improvement in outcomes over the past 3 decades. The unique brainstem location and the invasive nature of DIPG is suboptimally represented in modern therapeutic models and ...

PBTC-058: Phase 2 Study of Intraventricular Omburtamab-based Radioimmunotherapy for Pediatric Patients ...

Medulloblastoma is the second most common malignant brain tumor of childhood. Treatment consists of a combined-modality approach including surgery, radiotherapy and chemotherapy in most patients. Medulloblastoma relapse (rMB) occurs in approximately 30% of patients, is universally fatal and accounts for 10% of all childhood cancer deaths. Thus, there is ...