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Results: 218

Expansion of the International Diffuse Intrinsic Pontine Glioma (DIPG) Registry

Diffuse intrinsic pontine gliomas (DIPG) are the most common brainstem tumors in children, representing approximately 75-80% of all pediatric brainstem tumors. 1 Approximately 200-300 patients are diagnosed with DIPG in all of North America and Europe.  1,2 DIPG  accounts for 10-15% of all new pediatric brain tumor diagnoses and is ...

Exploring Combination Therapy for DIPG: SGI-110 and GAA Vaccine

Diffuse intrinsic pontine glioma (DIPG) are some of the deadliest childhood brain tumors. The immune system protects the body by recognizing targets on harmful cells, but tumor cells can “switch off” the targets and hide from the immune system. We have been using a vaccine that can target ...

Validation of the MethylationEPIC array Platform for Medulloblastoma Molecular Subgrouping ...

Medulloblastoma (MB) is the most common malignant brain tumor of childhood, accounting for nearly 25-30% of primary central nervous system tumors in children. Therapy options are divided into standard risk and high risk categories based on the age of the patient at presentation, the amount of tumor remaining after surgery, ...

Exploring the brain-gut-microbiota axis to characterize and predict outcome in ...

Abstract Diffuse intrinsic pontine gliomas (DIPGs), represent a group of malignancies with rapid onset of devastating neurologic symptoms associated with the local extension, poor response to adjuvant therapy and a very poor prognosis. Radiotherapy has remained the only modality of treatment with proven transient symptomatic improvement and represents the mainstay ...

Modulating the DIPG microenvironment with virus and complement inhibitors as ...

Diffuse intrinsic pontine glioma (DIPG) is one of the most formidable challenges faced by pediatric oncologists. For the last 30 years, all treatment approaches for these type of tumors have failed, leaving a terrible prospect of survival at 5 years for these children virtually of zero. Thus, it is clear that new ...