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Results: 51

Diffuse Intrinsic Pontine Glioma.

In tumors like DIPG, the diagnosis itself spells a death sentence for the child affected. For several decades, none of the altered fractionation radiotherapy or additional chemotherapy or targeted agents have shown a significant benefit over conventional radiotherapy. We propose amalgamation of several known and tested hypothesis in DIPG ...

CHARACTERIZATION OF THE ROLE OF L3MBTL3 IN MEDULLOBLASTOMA

LAY ABSTRACT: Millions of cells are formed every day in the developing brain of children. Medulloblastoma, a pediatric tumor, occurs when the proliferation of cells in the cerebellum (a lower part of the brain) becomes uncontrolled. The Notch pathway is a key mechanism that governs cell proliferation in many biological ...

Epigenetic reprogramming as a treatment option for NF1

Neurofibromatosis type 1 (NF1) is common, occurring in 1/3000 live births, and results in skin pigmentation and the growth of tumors along nerves in the skin, brain, and other parts of the body. It arises from a mutated and non-functional tumor suppressor bearing its name.  Tumors of the peripheral nerves, called ...

Exploring Combination Therapy for DIPG: SGI-110 and GAA Vaccine

Diffuse intrinsic pontine glioma (DIPG) are some of the deadliest childhood brain tumors. The immune system protects the body by recognizing targets on harmful cells, but tumor cells can “switch off” the targets and hide from the immune system. We have been using a vaccine that can target ...

Development of immunocompetent animal models for pediatric high-grade glioma and ...

Brain tumors are the leading cause of cancer-related death in children, with high-grade glioma (pHGG) and diffuse intrinsic pontine glioma (DIPG) carrying the worst prognosis, with no chance of cure. Over the past years, the prognosis of other aggressive cancer types has improved thanks to scientific breakthroughs in the field ...