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Results: 85


LAY ABSTRACT: Millions of cells are formed every day in the developing brain of children. Medulloblastoma, a pediatric tumor, occurs when the proliferation of cells in the cerebellum (a lower part of the brain) becomes uncontrolled. The Notch pathway is a key mechanism that governs cell proliferation in many biological ...

Therapeutic targeting of NTRK2 rearrangements in diffuse midline glioma

Lay Summary   Diffuse midline glioma (DMG) is a malignant brain tumour arising in children representing a major unmet clinical need, with a 2-year survival rate close to zero. We recently discovered a proportion of children with DMG to have small genetic alterations in a gene called NTRK2. Although not ...

Epigenetic reprogramming as a treatment option for NF1

Neurofibromatosis type 1 (NF1) is common, occurring in 1/3000 live births, and results in skin pigmentation and the growth of tumors along nerves in the skin, brain, and other parts of the body. It arises from a mutated and non-functional tumor suppressor bearing its name.  Tumors of the peripheral nerves, called ...

Clinical, radiologic, and molecular characteristics of anaplastic pleomorphic xanthoastrocytomas

  Pleomorphic xanthoastrocytomas (PXAs) are uncommon brain cancers in children and young adults. World Health Organization (WHO) grade II PXAs (low-grade gliomas), which account for most such tumors, can be cured by complete surgery. Aggressive variants (i.e., anaplastic PXAs), which are rare, were only recognized by the WHO classification ...

Exploring Combination Therapy for DIPG: SGI-110 and GAA Vaccine

Diffuse intrinsic pontine glioma (DIPG) are some of the deadliest childhood brain tumors. The immune system protects the body by recognizing targets on harmful cells, but tumor cells can “switch off” the targets and hide from the immune system. We have been using a vaccine that can target ...