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Results: 178

Investigating the impact of radiation toxicity on immune response in ...

Abstract: Cancer is a disease caused by changes in the genes and a leading cause of death worldwide. Cancer treatment is challenging despite years of innovations and research. In advanced stage, it is largely incurable and poorer prognosis. Radiotherapy is one of the effective means of managing advanced stage ...

Mapping DIPG Tumour Progression and understanding Biological Heterogeneity using Spatial ...

Diffuse Intrinsic Pontine Glioma (DIPG) otherwise known as Diffuse Midline Glioma (DMG) is a fatal brain stem glioma arising in young children. There are no effective therapies for DIPG and children typically succumb to the disease within 2 years. No therapy to-date has improved the survival rate for children with DIPG ...

Controlling DIPG/DMG with the protein kinase C-iota inhibitor ICA-1...

Pediatric Diffuse Intrinsic Pontine Glioma (DIPG) and Diffuse Midline Glioma (DMG) are currently incurable childhood brain tumors. Elucidating the regulation of signaling pathways in pediatric DIPG and DMG is critical to targeting tumor cell migration and spreading.  Until these pathways are understood, comprehensive and effective treatment of this group ...

The current situation of childhood brain tumor long-term survivors in ...

Central nervous system tumors, represent the highest mortality rate of all childhood malignancies, Nevertheless, the number of survivors of pediatric Brain tumors continues to increase. Gradually improving survival rates and a growing population of long-term survivors have expanded the focus of research, Increased attention has been given to late ...

Interaction of Immune System with Oncolytic Measles Virus Therapy of ...

Medulloblastoma (MB) is the most common malignant brain tumor in children. The Group 3 MB patients have the worst prognosis and dismal 5-year survival rate among the four distinct subtypes of MB: WNT, SHH, Group 3 and Group 4 tumors. Sadly, MB survivors face life-long debilitating neurocognitive side effects from craniospinal radiation that ...