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Results: 178

Targeting Histone Lysine Demethylases to Treat Diffuse Intrinsic Pontine Glioma

Diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPG), are devastating childhood brain tumors that occur in the central portions of the brain. Traditional chemotherapies do not work on them, and because of their location they cannot be removed by surgery. Radiation therapy slows tumor growth, but progression is ...

Assessing the potential of the HDAC inhibitor givinostat ± radiotherapy ...

Pediatric brain tumors are the most frequent childhood solid tumors, and the leading cause of cancer related death in children. Patients with a diffuse intrinsic pontine glioma (DIPG) or midline glioma (DMG) – located in the brainstem, thalamus, or spinal cord – have a particularly bad prognosis. These tumors often ...

MOLECULAR ANALYSIS OF DIFFUSE INTRINSIC PONTINE GLIOMAS

Brainstem gliomas constitute 10 to 15% of all brain tumors in children. Diffuse intrinsic pontine gliomas (DIPG) account for 80% of all brainstem tumors. The treatment of children with DIPG represents a formidable challenge because of the critical location of these tumors, and their refractoriness to therapy. Surgery to confirm the diagnosis is ...

Characterizing resistance mechanisms to radiation therapy and adjuvant chemotherapy in ...

Children diagnosed with Diffuse Intrinsic Pontine Gliomas (DIPGs) face a dismal prognosis, with rampant progression after initial therapy with chemoradiation and a median survival of less than two years. These tumors are universally fatal, with tumors rapidly exhibiting resistance to the current treatments. Therapeutic strategies that delay or ablate the ...

Establishment of an International Diffuse Intrinsic Pontine Glioma Registry (DIPG ...

Brainstem gliomas account for up to 20% of all CNS tumors in children with a median age at presentation of 6-7 years.1  Diffuse intrinsic pontine gliomas (DIPG) comprise 80% of all brainstem gliomas. In North America and Europe, approximately 300 children develop brainstem gliomas per year. 2 Prognosis for patients with DIPGs remains ...