Targeting Histone Lysine Demethylases to Treat Diffuse Intrinsic Pontine Glioma
Diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPG), are devastating childhood brain tumors that occur in the central portions of the brain. Traditional chemotherapies do not work on them, and because of their location they cannot be removed by surgery. Radiation therapy slows tumor growth, but progression is ...