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Results: 178

Controlling DIPG/DMG with the protein kinase C-iota inhibitor ICA-1...

Pediatric Diffuse Intrinsic Pontine Glioma (DIPG) and Diffuse Midline Glioma (DMG) are currently incurable childhood brain tumors. Elucidating the regulation of signaling pathways in pediatric DIPG and DMG is critical to targeting tumor cell migration and spreading.  Until these pathways are understood, comprehensive and effective treatment of this group ...

Targeting Glycolysis for Inhibition of Tumor Growth in Pediatric Brain ...

Pediatric brain tumors have limited responses to conventional therapeutic option and high mortality rates. Novel approaches to treat these and other forms of cancer involve targeting metabolic mechanisms of cancer cells from which they derive energy. These include aerobic glycolysis or the Warburg effect; named after Otto Warburg who first ...

Interaction of Immune System with Oncolytic Measles Virus Therapy of ...

Medulloblastoma (MB) is the most common malignant brain tumor in children. The Group 3 MB patients have the worst prognosis and dismal 5-year survival rate among the four distinct subtypes of MB: WNT, SHH, Group 3 and Group 4 tumors. Sadly, MB survivors face life-long debilitating neurocognitive side effects from craniospinal radiation that ...

Photodynamic therapy of diffuse intrinsic pontine glioma in combination with ...

Diffuse intrinsic pontine glioma (DIPG) is a lethal childhood brain tumor and a leading cause of pediatric brain tumor-related mortality. Even with treatment, the median survival of patients with DIPG is 9–11 months. Despite a number of clinical trials, no treatments have proven more effective than radiation therapy (RT) for ...

Radionuclide therapy for somatostatin receptor-positive high-grade central nervous system tumors ...

Abstract: Brain and spine tumors are the leading cause of cancer-related death in children and adolescents. While cure can sometimes be achieved with conventional chemotherapy, surgery, and/or radiation, prognosis is dismal for patients whose aggressive brain/spine tumors progress despite these treatments. There is a critical need to develop ...